Research Topics

Genomes and Genes

Gene Symbol: yciB

Description: intracellular septation protein A

Species: Shigella flexneri 2a str. 301

Hong M, Gleason Y, Wyckoff E, Payne S. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Infect Immun. 1998;66:4700-10 pubmed

..flexneri. The mutant with the insertion at 28 min was interrupted in the same open reading frame as S. flexneri ispA. This ispA mutant could not form plaques and was defective in bacterial septation inside tissue culture cells...
Mac S om in R, Nakata N, Murai T, Yoshikawa M, Tsuji H, Sasakawa C. Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intracellular spreading. Mol Microbiol. 1996;19:599-609 pubmed

..These results thus show that ispA is an essential virulence gene affecting several functions of the virulence process...