Gene Symbol: gyrA
Description: DNA gyrase subunit A
Species: Shigella flexneri 2a str. 301

Top Publications

  1. Morais Cabral J, Jackson A, Smith C, Shikotra N, Maxwell A, Liddington R. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature. 1997;388:903-6 pubmed publisher
    ..Mutations that confer resistance to the quinolone antibacterial agents cluster at the new dimer interface, indicating how these drugs might interact with the gyrase-DNA complex...
  2. Divya M, Mathew P, Jyothi R, Bai R, Thomas S. Mutations in gyrA & parC genes of Shigella flexneri 2a determining the fluoroquinolone resistance. Indian J Med Res. 2015;141:836-8 pubmed publisher
  3. Tamanna -, Ramana J. Structural Insights into the Fluoroquinolone Resistance Mechanism of Shigella flexneri DNA Gyrase and Topoisomerase IV. Microb Drug Resist. 2016;22:404-11 pubmed publisher
    ..In this work, we performed docking studies of DNA gyraseA (GyrA) and topoisomerase IV (ParC) of Shigella flexneri and their mutants with two different fluoroquinolones, ..