SPP1

Summary

Gene Symbol: SPP1
Description: secreted phosphoprotein 1
Alias: OPN, osteopontin, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Species: sheep

Publications

  1. Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:884-91
  2. Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:892-9
  3. Progesterone modulation of osteopontin gene expression in the ovine uterus
    G A Johnson
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1315-21
  4. Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis
    S S Barros
    Department of Pathology, Federal University of Pelotas, CEP 96010 900 Pelotas, Brazil
    J Comp Pathol 123:270-7
  5. Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8
  6. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8
  7. Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8
  8. Immunohistochemical localization of integrin alpha V beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants
    Sarah Kimmins
    Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS INSERM Université Louis Pasteur, B P 16367404 Illkirch, Strasbourg, France
    Reprod Biol Endocrinol 2:19

Scientific Experts

Detail Information

Publications8

  1. Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:884-91
    ..Our hypothesis was that the 70-kDa acidic protein is osteopontin (OPN)...
  2. Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:892-9
    b>Osteopontin (OPN) is an acidic 70-kDa glycoprotein that is cleaved by proteases to yield 45-kDa and 24-kDa fragments...
  3. Progesterone modulation of osteopontin gene expression in the ovine uterus
    G A Johnson
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1315-21
    b>Osteopontin (OPN) is an acidic phosphorylated glycoprotein component of the extracellular matrix that binds to integrins at the cell surface to promote cell-cell attachment and cell spreading...
  4. Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis
    S S Barros
    Department of Pathology, Federal University of Pelotas, CEP 96010 900 Pelotas, Brazil
    J Comp Pathol 123:270-7
    ..Thickening and replication of the basal lamina of capillaries were prominent. The bone proteins osteocalcin, osteopontin and osteonectin were detected immunohistochemically in the cytoplasm of activated fibroblasts, in modified SMCs ..
  5. Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8
    The extracellular matrix protein osteopontin (OPN) is a component of histotroph that increases in uterine flushings from pregnant ewes during the peri-implantation period and is localized on the apical surfaces of the uterine luminal ..
  6. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8
    b>Osteopontin (OPN) is a phosphorylated and glycosylated, secreted protein that is present in various epithelial cells and biological fluids...
  7. Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8
    b>Osteopontin (OPN) is a component of the extracellular matrix that interacts with cell surface receptors, including integrins, to mediate cell adhesion, migration, differentiation, survival, and immune function...
  8. Immunohistochemical localization of integrin alpha V beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants
    Sarah Kimmins
    Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS INSERM Université Louis Pasteur, B P 16367404 Illkirch, Strasbourg, France
    Reprod Biol Endocrinol 2:19
    ..has been suggested that trophoblast attachment requires co-expression of integrin alpha V beta 3 and its ligand osteopontin at the fetal-maternal interface...