SPP1

Summary

Gene Symbol: SPP1
Description: secreted phosphoprotein 1
Alias: OPN, SPP-1, bone sialoprotein 1, osteopontin, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Species: sheep

Top Publications

  1. ncbi Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:892-9. 1999
  2. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
  3. ncbi Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8. 2001
  4. ncbi Progesterone modulation of osteopontin gene expression in the ovine uterus
    G A Johnson
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1315-21. 2000
  5. ncbi Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:884-91. 1999
  6. ncbi Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis
    S S Barros
    Department of Pathology, Federal University of Pelotas, CEP 96010 900 Pelotas, Brazil
    J Comp Pathol 123:270-7. 2000
  7. ncbi Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8. 2003
  8. pmc Immunohistochemical localization of integrin alpha V beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 16367404 Illkirch, Strasbourg, France
    Reprod Biol Endocrinol 2:19. 2004
  9. ncbi The Interaction between female sex hormone receptors and osteopontin in a rat hyperoxaluric model
    Jiro Miyajima
    Department of Urology, Kurume University School of Medicine, Kurume, Japan
    Kurume Med J 57:73-80. 2010

Scientific Experts

Detail Information

Publications9

  1. ncbi Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:892-9. 1999
    b>Osteopontin (OPN) is an acidic 70-kDa glycoprotein that is cleaved by proteases to yield 45-kDa and 24-kDa fragments...
  2. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    b>Osteopontin (OPN) is a phosphorylated and glycosylated, secreted protein that is present in various epithelial cells and biological fluids...
  3. ncbi Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8. 2001
    The extracellular matrix protein osteopontin (OPN) is a component of histotroph that increases in uterine flushings from pregnant ewes during the peri-implantation period and is localized on the apical surfaces of the uterine luminal ..
  4. ncbi Progesterone modulation of osteopontin gene expression in the ovine uterus
    G A Johnson
    Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Center, College Station, Texas 77843 2471, USA
    Biol Reprod 62:1315-21. 2000
    b>Osteopontin (OPN) is an acidic phosphorylated glycoprotein component of the extracellular matrix that binds to integrins at the cell surface to promote cell-cell attachment and cell spreading...
  5. ncbi Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period
    G A Johnson
    Department of Animal Science, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, College Station, Texas 77843 2471, USA
    Biol Reprod 61:884-91. 1999
    ..Our hypothesis was that the 70-kDa acidic protein is osteopontin (OPN)...
  6. ncbi Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis
    S S Barros
    Department of Pathology, Federal University of Pelotas, CEP 96010 900 Pelotas, Brazil
    J Comp Pathol 123:270-7. 2000
    ..Thickening and replication of the basal lamina of capillaries were prominent. The bone proteins osteocalcin, osteopontin and osteonectin were detected immunohistochemically in the cytoplasm of activated fibroblasts, in modified SMCs ..
  7. ncbi Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 68:1951-8. 2003
    b>Osteopontin (OPN) is a component of the extracellular matrix that interacts with cell surface receptors, including integrins, to mediate cell adhesion, migration, differentiation, survival, and immune function...
  8. pmc Immunohistochemical localization of integrin alpha V beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 16367404 Illkirch, Strasbourg, France
    Reprod Biol Endocrinol 2:19. 2004
    ..has been suggested that trophoblast attachment requires co-expression of integrin alpha V beta 3 and its ligand osteopontin at the fetal-maternal interface...
  9. ncbi The Interaction between female sex hormone receptors and osteopontin in a rat hyperoxaluric model
    Jiro Miyajima
    Department of Urology, Kurume University School of Medicine, Kurume, Japan
    Kurume Med J 57:73-80. 2010
    ..of estrogen receptor-α (ERα), estrogen receptor-related receptor-α (ERRα), and stone matrix protein osteopontin (OPN) in a rat hyperoxaluric model and in primary cultured rat kidney cells...