Research Topics
| PRPCSummaryGene Symbol: PRPC Description: prion protein Species: sheep Publications Compartmentalization of prion isoforms within the reproductive tract of the ramHeath Ecroyd Gamètes Males et Fertilit, UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux, Station de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France Biol Reprod 71:993-1001 Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversionAlan Rigter Central Institute for Animal Disease Control, Department of Bacteriology and TSEs, PO Box 2004, 8203 AA Lelystad, The Netherlands J Gen Virol 86:2627-34 Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteinsKirill Tsiroulnikov Institut National de la Recherche Agronomique, BIA-FIPL, B.P. 71627, F-44316 Nantes Cedex 3, France Biochim Biophys Acta 1764:1218-26 Investigating the relationship between the prion protein locus and udder morphology traits and milk yield in Sardinian sheepS Salaris Istituto Zootecnico e Caseario per la Sardegna, 07040 Olmedo, Italy J Anim Sci 85:2840-5 Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancyPatama Thumdee Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Bonn, Germany Gene Expr 13:283-97 Copper(II) inhibits in vitro conformational conversion of ovine prion protein triggered by low pHMei-li Liu National Animal TSE Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China J Biochem 143:333-7 Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placentaJ M Evoniuk Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA Placenta 29:422-8 | Scientific Experts
|
Detail Information
Publications
Compartmentalization of prion isoforms within the reproductive tract of the ramHeath Ecroyd
Gamètes Males et Fertilit, UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux, Station de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
Biol Reprod 71:993-1001
Gamètes Males et Fertilit, UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux, Station de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
Biol Reprod 71:993-1001
..In sperm, this C-terminal truncated form was found to be associated with membrane lipid rafts present in the mature sperm, suggesting a role for it in the terminal stages of sperm maturation...
Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversionAlan Rigter
Central Institute for Animal Disease Control, Department of Bacteriology and TSEs, PO Box 2004, 8203 AA Lelystad, The Netherlands
J Gen Virol 86:2627-34
Central Institute for Animal Disease Control, Department of Bacteriology and TSEs, PO Box 2004, 8203 AA Lelystad, The Netherlands
J Gen Virol 86:2627-34
Conversion of the host-encoded protease-sensitive cellular prion protein (PrPC) into the scrapie-associated protease-resistant isoform (PrPSc) of prion protein (PrP) is the central event in transmissible spongiform encephalopathies or ..
Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteinsKirill Tsiroulnikov
Institut National de la Recherche Agronomique, BIA-FIPL, B.P. 71627, F-44316 Nantes Cedex 3, France
Biochim Biophys Acta 1764:1218-26
Institut National de la Recherche Agronomique, BIA-FIPL, B.P. 71627, F-44316 Nantes Cedex 3, France
Biochim Biophys Acta 1764:1218-26
..This could imply also that other factors than physico-chemical differences between PrP-VRQ and PrP-ARR and the differences in PrP transformation are responsible for the onset of TSE...
Investigating the relationship between the prion protein locus and udder morphology traits and milk yield in Sardinian sheepS Salaris
Istituto Zootecnico e Caseario per la Sardegna, 07040 Olmedo, Italy
J Anim Sci 85:2840-5
Istituto Zootecnico e Caseario per la Sardegna, 07040 Olmedo, Italy
J Anim Sci 85:2840-5
..However, a loss of genetic gain for milk yield is likely to occur in the future due to the different selection pressures on resistant and susceptible males...
Expression of the prion protein gene (PRNP) and cellular prion protein (PrPc) in cattle and sheep fetuses and maternal tissues during pregnancyPatama Thumdee
Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Bonn, Germany
Gene Expr 13:283-97
Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Bonn, Germany
Gene Expr 13:283-97
..05). Western blot analyses revealed the immunoreactive bands corresponding to the cellular prion protein (PrPc) in all maternal and fetal tissues examined of both cattle and sheep...
Copper(II) inhibits in vitro conformational conversion of ovine prion protein triggered by low pHMei-li Liu
National Animal TSE Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China
J Biochem 143:333-7
National Animal TSE Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China
J Biochem 143:333-7
..This study demonstrated that Cu(2+) can significantly modulate conformational conversion triggered by acidic pH, and this will provide therapeutic intervention approaches for prion diseases...
Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placentaJ M Evoniuk
Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA
Placenta 29:422-8
Department of Animal and Range Sciences, North Dakota State University, 1300 Albrecht Boulevard, Fargo, ND 58105, USA
Placenta 29:422-8
For placental transmission of scrapie to occur, the normal cellular prion protein (PrPC) must be converted to an abnormal infectious form known as PrPSc...