OTR

Summary

Gene Symbol: OTR
Description: oxytocin receptor
Alias: OT-R, OXTR, endometrial oxytocin receptor
Species: sheep

Publications

  1. Functional characterisation of an ovine endometrial oxytocin receptor cDNA transiently expressed in Cos-7 cells
    P R Riley
    Department of Physiology, Royal Free Hospital School of Medicine, London, UK
    J Endocrinol 149:389-96
  2. The sheep endometrial oxytocin receptor
    A P Flint
    Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire, United Kingdom
    Adv Exp Med Biol 395:281-94
  3. Structure and expression of an ovine endometrial oxytocin receptor cDNA
    P R Riley
    Institute of Zoology, Regents Park, London, UK
    J Mol Endocrinol 15:195-202
  4. Regulation of oxytocin receptor gene expression in sheep: tissue specificity, multiple transcripts and mRNA editing
    H C Feng
    Centre for Bioprocessing and Food Technology, Victoria University of Technology, PO Box 14428, MCMC Melbourne, Victoria 8001 Australia
    J Reprod Fertil 120:187-200
  5. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements
    Joann G W Fleming
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:899-911

Detail Information

Publications5

  1. Functional characterisation of an ovine endometrial oxytocin receptor cDNA transiently expressed in Cos-7 cells
    P R Riley
    Department of Physiology, Royal Free Hospital School of Medicine, London, UK
    J Endocrinol 149:389-96
    The entire coding region of an ovine endometrial oxytocin receptor (OTR) cDNA was generated by PCR, subcloned into the SV40 major late promoter expression vector pSVLJ and transiently expressed in Cos-7 cells...
  2. The sheep endometrial oxytocin receptor
    A P Flint
    Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire, United Kingdom
    Adv Exp Med Biol 395:281-94
    The sheep endometrial oxytocin receptor plays a central role in determining the time at which luteolysis occurs during the oestrous cycle, and in the events leading to the establishment of pregnancy (the maternal recognition of pregnancy)..
  3. Structure and expression of an ovine endometrial oxytocin receptor cDNA
    P R Riley
    Institute of Zoology, Regents Park, London, UK
    J Mol Endocrinol 15:195-202
    A sheep endometrial oxytocin receptor (OTR) cDNA (1.5 kb) was isolated from a lambda-ZAP library using a reverse transcription-PCR product probe generated from oestrous endometrial mRNA...
  4. Regulation of oxytocin receptor gene expression in sheep: tissue specificity, multiple transcripts and mRNA editing
    H C Feng
    Centre for Bioprocessing and Food Technology, Victoria University of Technology, PO Box 14428, MCMC Melbourne, Victoria 8001 Australia
    J Reprod Fertil 120:187-200
    ..mRNA editing of oxytocin receptor transcripts may be reflected in changes in the amino acid composition of the carboxyl terminus of the receptor, which would explain the differences in the observed responses to an oxytocin challenge...
  5. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements
    Joann G W Fleming
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:899-911
    ..In cyclic ewes, loss of PGR allows for increases in estrogen receptor alpha (ESR1) and then oxytocin receptor (OXTR) gene expression followed by oxytocin-induced prostaglandin F(2alpha) pulses...