Gene Symbol: NOS2
Description: nitric oxide synthase 2
Alias: INOS, NOS2A, nitric oxide synthase, inducible, inducible nitric oxide synthase, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes)
Kwon H, Wu G, Meininger C, Bazer F, Spencer T. Developmental changes in nitric oxide synthesis in the ovine placenta. Biol Reprod. 2004;70:679-86 pubmed publisher
..Tissues were analyzed for constitutive NOS (cNOS) and inducible NOS (iNOS) activities, NO synthesis, tetrahydrobiopterin (BH4) and NADPH (essential cofactors for NOS), and GTP-..
Mershon J, Baker R, Clark K. Estrogen increases iNOS expression in the ovine coronary artery. Am J Physiol Heart Circ Physiol. 2002;283:H1169-80 pubmed
..In this study, we investigated the possibility that transcriptional activation of inducible NO synthase (iNOS) is responsible for a component of the estrogen-induced increase in coronary blood flow...
Wood C, Chen G, Keller Wood M. Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstem. Am J Physiol Regul Integr Comp Physiol. 2005;289:R613-R619 pubmed publisher
..Neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) mRNA was measured using real-time PCR methodology specific for ovine NOS isoforms...
Enkhbaatar P, Murakami K, Traber L, Cox R, Parkinson J, Westphal M, et al
. The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock. 2006;25:522-7 pubmed publisher
..We hypothesized that the inhibition of iNOS-derived excessive NO might be beneficial in treating the cardiopulmonary derangement in this model...
Cox R, Jacob S, Oliveras G, Murakami K, Enkhbaatar P, Traber L, et al
. Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury. Exp Lung Res. 2009;35:104-18 pubmed publisher
Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung...
Kameny R, He Y, Morris C, Sun C, Johengen M, Gong W, et al
. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015;309:H157-65 pubmed publisher
..These data demonstrate preserved fetal NOS phenotype and NO signaling in shunt RV, which may partially explain the mechanism underlying the adaptive response to increased afterload seen in the RV of shunt lambs. ..