MMP2

Summary

Gene Symbol: MMP2
Description: matrix metallopeptidase 2
Alias: MMP-2, 72 kDa type IV collagenase, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Species: sheep

Top Publications

  1. Ricke W, Smith G, Smith M. Matrix metalloproteinase expression and activity following prostaglandin F(2 alpha)-induced luteolysis. Biol Reprod. 2002;66:685-91 pubmed
    ..MMP mRNA expression and activity were significantly increased following PGF(2 alpha) treatment. Increased MMP activity may promote ECM degradation during luteolysis. ..
  2. Jackson M, Smith M, Smith S, Jackson C, Xue M, Little C. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis Rheum. 2009;60:780-91 pubmed publisher
    ..APC could not directly activate proMMP-13, but it was associated with increased MMP-2 and MMP-9 activity. APC may be a relevant activator of MMPs in cartilage and may play a role in progressive cartilage degradation in arthritis...
  3. Ferraz K, Sousa Santos O, Neto Neves E, Rizzi E, Muniz J, Gerlach R, et al. Recombinant human matrix metalloproteinase-2 impairs cardiovascular ?-adrenergic responses. Basic Clin Pharmacol Toxicol. 2013;112:103-9 pubmed publisher
    ..Our findings show that rhMMP-2 exerts no major haemodynamic effects in lambs. However, rhMMP-2 impairs the responses elicited by activation of ?-adrenoreceptors...
  4. Weaver Mikaere L, Gunn A, Bennet L, Mitchell M, Fraser M. Inhibition of matrix metalloproteinases-2/-9 transiently reduces pre-oligodendrocyte loss during lipopolysaccharide- but not tumour necrosis factor-alpha-induced inflammation in fetal ovine glial culture. Dev Neurosci. 2013;35:461-73 pubmed publisher
    ..Collectively, these observations suggest a limited, transient effect of MMPs on immature white matter damage associated with infection but not TNF-?-mediated inflammation. ..