Research Topics

Genomes and Genes




Gene Symbol: MIP
Description: major intrinsic protein of lens fiber
Alias: AQP0, lens fiber major intrinsic protein, Aquaporin-0, aquaporin 0
Species: sheep

Top Publications

  1. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004;429:193-7 pubmed
    The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo...
  2. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison S, et al. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005;438:633-8 pubmed
    Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1...
  3. Scheuring S, Buzhynskyy N, Jaroslawski S, Gonçalves R, Hite R, Walz T. Structural models of the supramolecular organization of AQP0 and connexons in junctional microdomains. J Struct Biol. 2007;160:385-94 pubmed
    ..of junctional microdomains in native eye lens membranes containing two-dimensional (2D) arrays of aquaporin-0 (AQP0) surrounded by connexons...
  4. Berthaud A, Manzi J, P rez J, Mangenot S. Modeling detergent organization around aquaporin-0 using small-angle X-ray scattering. J Am Chem Soc. 2012;134:10080-8 pubmed publisher
    ..For the first time, the partial specific volume of the detergent surrounding a protein was measured. The present protocol is a crucial step toward future conformational studies of membrane proteins in solution...
  5. Hite R, Chiu P, Schuller J, Walz T. Effect of lipid head groups on double-layered two-dimensional crystals formed by aquaporin-0. PLoS ONE. 2015;10:e0117371 pubmed publisher
    Aquaporin-0 (AQP0) is a lens-specific water channel that also forms membrane junctions. Reconstitution of AQP0 with dimyristoyl phosphatidylcholine (DMPC) and E...
  6. Saboe P, Rapisarda C, Kaptan S, Hsiao Y, Summers S, De Zorzi R, et al. Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0. Biophys J. 2017;112:953-965 pubmed publisher
    Compared to other aquaporins (AQPs), lens-specific AQP0 is a poor water channel, and its permeability was reported to be pH-dependent...