Gene Symbol: HYAL2
Description: hyaluronoglucosaminidase 2
Alias: oHyal2, hyaluronidase-2, GPI-anchored surface protein, JSRV envelope protein receptor, hyal-2
Species: sheep

Top Publications

  1. Rai S, Duh F, Vigdorovich V, Danilkovitch Miagkova A, Lerman M, Miller A. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001;98:4443-8 pubmed
    ..used phenotypic screening of radiation hybrid cell lines to identify the candidate lung cancer tumor suppressor HYAL2/LUCA2 as the receptor for JSRV...
  2. Dirks C, Duh F, Rai S, Lerman M, Miller A. Mechanism of cell entry and transformation by enzootic nasal tumor virus. J Virol. 2002;76:2141-9 pubmed
    ..the ENTV Env protein mediates virus entry using the same receptor as does JSRV Env, the candidate tumor suppressor Hyal2. However, ENTV Env mediates entry into cells from a more restricted range of species than does JSRV, and based on ..