GDF9

Summary

Gene Symbol: GDF9
Description: growth differentiation factor 9
Alias: GDF-9, growth/differentiation factor 9
Species: sheep
Products:     GDF9

Top Publications

  1. Bebbere D, Bogliolo L, Ariu F, Fois S, Leoni G, Tore S, et al. Expression pattern of zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in ovine oocytes and in vitro-produced preimplantation embryos. Reprod Fertil Dev. 2008;20:908-15 pubmed
    ..effect genes (MEG), namely zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), were determined in ovine oocytes and in vitro-..
  2. Nicol L, Bishop S, Pong Wong R, Bendixen C, Holm L, Rhind S, et al. Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep. Reproduction. 2009;138:921-33 pubmed publisher
    ..In the present study we present a detailed characterization of a novel mutation in growth differentiation factor 9 (GDF9), found in Icelandic Thoka sheep...
  3. Silva B, Castro E, Souza C, Paiva S, Sartori R, Franco M, et al. A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep. Anim Genet. 2011;42:89-92 pubmed publisher
    ..A high rate of twin births was reported in some SI flocks. Growth and Differentiation Factor 9 (GDF9) and Bone Morphogenetic Protein 15 (BMP15) are the first two genes expressed by the oocyte to be associated with an ..
  4. Mullen M, Hanrahan J, Howard D, Powell R. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep. PLoS ONE. 2013;8:e53172 pubmed publisher
    ..in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecX(G) and FecX(B)) and the third (FecG(H)) in GDF9. All three mutations segregate in Belclare sheep while one, FecX(B), has not been found in the Cambridge...
  5. Vage D, Husdal M, Kent M, Klemetsdal G, Boman I. A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep. BMC Genet. 2013;14:1 pubmed publisher
    ..A QTL-region was identified on sheep chromosome 5, close to the growth differentiation factor 9 (GDF9), which is known to be a strong candidate gene for increased ovulation rate/litter size...
  6. Bodensteiner K, Clay C, Moeller C, Sawyer H. Molecular cloning of the ovine Growth/Differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries. Biol Reprod. 1999;60:381-6 pubmed
  7. Feary E, Juengel J, Smith P, French M, O Connell A, Lawrence S, et al. Patterns of expression of messenger RNAs encoding GDF9, BMP15, TGFBR1, BMPR1B, and BMPR2 during follicular development and characterization of ovarian follicular populations in ewes carrying the Woodlands FecX2W mutation. Biol Reprod. 2007;77:990-8 pubmed publisher
    ..not appear to be due to the previously described mutations in bone morphogenetic protein 15 (BMP15), growth differentiation factor 9 (GDF9), or bone morphogenetic protein receptor type 1B (BMPR1B) that affect ovulation rate in sheep...
  8. Khodabakhshzadeh R, Mohammadabadi M, Esmailizadeh A, Moradi Shahrebabak H, Bordbar F, Ansari Namin S. Identification of point mutations in exon 2 of GDF9 gene in Kermani sheep. Pol J Vet Sci. 2016;19:281-9 pubmed publisher
    ..The aim of this study was to detect single nucleotide polymorphisms (SNPs) in exon 2 of GDF9 gene in Kermani sheep breed using PCR-SSCP...
  9. Bravo S, Larama G, Paz E, Inostroza K, Montaldo H, Sepulveda N. Polymorphism of the GDF9 gene associated with litter size in Araucana creole sheep. Anim Genet. 2016;47:390-1 pubmed publisher

More Information

Publications17

  1. Kona S, Praveen Chakravarthi V, Siva Kumar A, Srividya D, Padmaja K, Rao V. Quantitative expression patterns of GDF9 and BMP15 genes in sheep ovarian follicles grown in vivo or cultured in vitro. Theriogenology. 2016;85:315-22 pubmed publisher
    Quantitative patterns of expression of the growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15) genes in different development stages of in vivo and in vitro grown ovarian follicles in sheep were studied ..
  2. Mullen M, Hanrahan J. Direct evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of Finnsheep. PLoS ONE. 2014;9:e95251 pubmed publisher
    ..with large effects on ovulation rate in sheep, or 2) any other DNA sequence variants within the candidate genes GDF9 and BMP15 are implicated in the high prolificacy of the Finnish Landrace breed; using material from lines developed ..
  3. Abdoli R, Zamani P, Deljou A, Rezvan H. Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes. Gene. 2013;524:296-303 pubmed publisher
    BMPR-1B and GDF9 genes are well known due to their important effects on litter size and mechanisms controlling ovulation rate in sheep...
  4. Roy J, Polley S, De S, Mukherjee A, Batabyal S, Pan S, et al. Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol. 2011;22:151-62 pubmed publisher
    ..All five loci of BMP15 and three loci of GDF 9 genes were monomorphic...
  5. Chu M, Yang J, Feng T, Cao G, Fang L, Di R, et al. GDF9 as a candidate gene for prolificacy of Small Tail Han sheep. Mol Biol Rep. 2011;38:5199-204 pubmed publisher
    b>Growth differentiation factor 9 (GDF9) which controls the fecundity of Belclare, Cambridge, Santa Ines, Moghani, Ghezel and Thoka ewes was studied as a candidate gene for the prolificacy of Small Tail Han sheep...
  6. Polley S, De S, Brahma B, Mukherjee A, Vinesh P, Batabyal S, et al. Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep. Trop Anim Health Prod. 2010;42:985-93 pubmed publisher
    ..the growth differentiation factor 9 (GDF9/FecG), bone morphogenetic protein 15 (BMP15/FecX) and associated type I receptors, bone ..
  7. Barzegari A, Atashpaz S, Ghabili K, Nemati Z, Rustaei M, Azarbaijani R. Polymorphisms in GDF9 and BMP15 associated with fertility and ovulation rate in Moghani and Ghezel sheep in Iran. Reprod Domest Anim. 2010;45:666-9 pubmed publisher
    ..genes encoding bone morphogenetic (BM) protein 15 and growth differentiation (GD) factor 9, respectively BMP15 and GDF9 have been shown to affect female productivity in domesticated sheep...
  8. Javanmard A, Azadzadeh N, Esmailizadeh A. Mutations in bone morphogenetic protein 15 and growth differentiation factor 9 genes are associated with increased litter size in fat-tailed sheep breeds. Vet Res Commun. 2011;35:157-67 pubmed publisher
    The objective of this study was to investigate association between GDF9 and BMP15 gene polymorphism and litter size in fat-tailed sheep, a total of 97 mature ewes from four breeds (Afshari=19; Baluchi=18; Makui=30 and Mehraban=30) were ..