BMPR1B

Summary

Gene Symbol: BMPR1B
Description: bone morphogenetic protein receptor type 1B
Alias: ALK6, BMPR-IB, FecB, bone morphogenetic protein receptor type-1B, BMP receptor IB, activin receptor-like kinase 6, bone morphogenetic protein receptor, type IB, bone morphogenetic protein type recepter 1B
Species: sheep

Top Publications

  1. Guan F, Liu S, Shi G, Yang L. Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Anim Reprod Sci. 2007;99:44-52 pubmed
    Nine sheep breeds or strains, including 615 individuals were screened with forced PCR RFLP method for the FecB gene to study the polymorphism and its effects on litter sizes, body weights and body sizes...
  2. Wilson T, Wu X, Juengel J, Ross I, Lumsden J, Lord E, et al. Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol Reprod. 2001;64:1225-35 pubmed
    The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1...
  3. Souza C, MacDougall C, Campbell B, McNeilly A, Baird D. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene. J Endocrinol. 2001;169:R1-6 pubmed
    ..The BMPR1B gene in the human is located at the region linked with the Booroola mutation, syntenic to chromosome 6 in the ..
  4. Mulsant P, Lecerf F, Fabre S, Schibler L, Monget P, Lanneluc I, et al. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes. Proc Natl Acad Sci U S A. 2001;98:5104-9 pubmed
    ..This phenotype is due to the action of the FecB(B) allele of a major gene named FecB, as determined by statistical analysis of phenotypic data...
  5. Mahdavi M, Nanekarani S, Hosseini S. Mutation in BMPR-IB gene is associated with litter size in Iranian Kalehkoohi sheep. Anim Reprod Sci. 2014;147:93-8 pubmed publisher
    ..The same FecB (Booroola) mutation occurred in the BMPR-IB gene in Kalehkoohi sheep as found in Booroola Merino...
  6. Hua G, Yang L. A review of research progress of FecB gene in Chinese breeds of sheep. Anim Reprod Sci. 2009;116:1-9 pubmed publisher
    b>FecB gene is a major gene responsible for high prolificacy firstly identified in Booroola Merino sheep. Subsequently, many other aspects of the FecB including endocrinology, fetal and postnatal growth were studied...
  7. Young J, Juengel J, Dodds K, Laird M, Dearden P, McNeilly A, et al. The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures. J Endocrinol. 2008;196:251-61 pubmed publisher
    ..cultured from Booroola ewes homozygous for a mutation in activin receptor-like kinase 6 (ALK6) also known as BMP receptor IB (BMPRIB), and from wild-type (WT) ewes to determine if the mutation caused alterations in FSH secretion in ..
  8. Chu M, Jia L, Zhang Y, Jin M, Chen H, Fang L, et al. Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep. Mol Biol Rep. 2011;38:4071-6 pubmed publisher
  9. Crawford J, Heath D, Reader K, Quirke L, Hudson N, Juengel J, et al. Oocytes in sheep homozygous for a mutation in bone morphogenetic protein receptor 1B express lower mRNA levels of bone morphogenetic protein 15 but not growth differentiation factor 9. Reproduction. 2011;142:53-61 pubmed publisher
    ..test the hypothesis that the high ovulation rate in ewes (BB) homozygous for a mutation in the bone morphogenetic protein receptor type 1B (BMPR1B) gene is linked to lower BMP15 and/or GDF9 mRNA in oocytes compared with those in wild-..

More Information

Publications20

  1. Reader K, Haydon L, Littlejohn R, Juengel J, McNatty K. Booroola BMPR1B mutation alters early follicular development and oocyte ultrastructure in sheep. Reprod Fertil Dev. 2012;24:353-61 pubmed publisher
    Booroola ewes homozygous (BB) for a mutation in the bone morphogenetic protein receptor-1b (BMPR1B) gene exhibit higher ovulation rates, have larger diameter oocytes at earlier stages of follicular development (i.e...
  2. Chu M, Liu Z, Jiao C, He Y, Fang L, Ye S, et al. Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). J Anim Sci. 2007;85:598-603 pubmed
    ..The results indicated that the same FecB mutation (Q249R) occurred in the BMPR-IB gene in Small Tailed Han ewes as found in Booroola Merino ewes...
  3. Polley S, De S, Brahma B, Mukherjee A, Vinesh P, Batabyal S, et al. Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep. Trop Anim Health Prod. 2010;42:985-93 pubmed publisher
    ..bone morphogenetic protein 15 (BMP15/FecX) and associated type I receptors, bone morphogenetic protein receptor (BMPR1B/FecB), are major determinant of ovulation rate and consequent increase in litter size...
  4. Abdoli R, Zamani P, Deljou A, Rezvan H. Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes. Gene. 2013;524:296-303 pubmed publisher
    ..Marker assisted selection using BMPR-IB gene could be noticed to improve the reproduction traits in Mehraban sheep. ..
  5. Wang W, Liu S, Li F, Pan X, Li C, Zhang X, et al. Polymorphisms of the Ovine BMPR-IB, BMP-15 and FSHR and Their Associations with Litter Size in Two Chinese Indigenous Sheep Breeds. Int J Mol Sci. 2015;16:11385-97 pubmed publisher
    ..Consequently, three polymorphisms, FecB mutation in BMPR-IB (c.746A>G), FecG mutation in BMP-15 (c.718C>T) and the mutation (g...
  6. Regan S, McFarlane J, O Shea T, Andronicos N, Arfuso F, Dharmarajan A, et al. Flow cytometric analysis of FSHR, BMRR1B, LHR and apoptosis in granulosa cells and ovulation rate in merino sheep. Reproduction. 2015;150:151-63 pubmed publisher
    ..up-regulation of FSH receptor (FSHR), transforming growth factor beta type 1, bone morphogenetic protein receptor (BMPR1B), and LH receptor (LHR) in BB sheep...
  7. Roy J, Polley S, De S, Mukherjee A, Batabyal S, Pan S, et al. Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol. 2011;22:151-62 pubmed publisher
    ..The FecB locus of the BMPR1B gene and two loci (G1 and G4) of GDF9 gene were found to be polymorphic...
  8. Xu Y, Li E, Han Y, Chen L, Xie Z. Differential expression of mRNAs encoding BMP/Smad pathway molecules in antral follicles of high- and low-fecundity Hu sheep. Anim Reprod Sci. 2010;120:47-55 pubmed publisher
    ..in Hu sheep and its relationship with the BMP/Smad pathway, 147 Hu sheep were blood sampled for detection of the FecB mutation (A746G) in the BMPRIB gene by PCR-SSCP, and sixteen adult Hu ewes classified as either high-fecundity (HF) ..
  9. Guan F, Liu S, Shi G, Ai J, Mao D, Yang L. Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Yi Chuan Xue Bao. 2006;33:117-24 pubmed
    Nine sheep breeds or strains, including 615 individuals were screened with forced PCR RFLP method for the FecB gene to study the polymorphism and its effects on litter size, body weight and body size...
  10. Chen X, Sun H, Tian S, Xiang H, Zhou L, Dun W, et al. Increasing litter size in a sheep breed by marker-assisted selection of BMPR1B A746G mutation. J Genet. 2015;94:139-42 pubmed
  11. Lecerf F, Foggia L, Mulsant P, Bonnet A, Hatey F. A novel method to isolate the common fraction of two DNA samples: hybrid specific amplification (HSA). Nucleic Acids Res. 2001;29:E87-7 pubmed
    ..Here we have successfully applied HSA to a particular tissue, but it should be possible to trap the common fraction of two DNA samples, whatever their nature. ..