Gene Symbol: P
Description: P protein
Species: Sendai virus
Horikami S, Smallwood S, Moyer S. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication. Virology. 1996;222:383-90 pubmed publisher
..Using the two-hybrid system we have confirmed the previously identified P-L (RNA polymerase), NPo-P (encapsidation substrate), and P-P complexes and now demonstrate NP-NP and NPo-V protein ..
Itoh M, Isegawa Y, Hotta H, Homma M. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. J Gen Virol. 1997;78 ( Pt 12):3207-15 pubmed publisher
Wiegand M, Bossow S, Schlecht S, Neubert W. De novo synthesis of N and P proteins as a key step in Sendai virus gene expression. J Virol. 2007;81:13835-44 pubmed publisher
..the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants...
Sakaguchi T, Irie T, Kuwayama M, Ueno T, Yoshida A, Kawabata R. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5. Microbiol Immunol. 2011;55:760-7 pubmed publisher
..Viral pathogenicity of SeV is related to the inhibitory effect of the V protein on MDA5, but is not always related to the binding of V protein with MDA5. ..
Irie T, Kiyotani K, Igarashi T, Yoshida A, Sakaguchi T. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J Virol. 2012;86:7136-45 pubmed publisher
..These results indicate that IRF3 is important as an alternative target of paramyxovirus V proteins. ..
Cevik B, Kaesberg J, Smallwood S, Feller J, Moyer S. Mapping the phosphoprotein binding site on Sendai virus NP protein assembled into nucleocapsids. Virology. 2004;325:216-24 pubmed publisher
To catalyze RNA synthesis, the Sendai virus P-L RNA polymerase complex first binds the viral nucleocapsid (NC) template through an interaction of the P subunit with NP assembled with the genome RNA...