Gene Symbol: HN
Description: hemagglutinin-neuraminidase protein
Species: Sendai virus
Gosselin Grenet A, Mottet Osman G, Roux L. Sendai virus particle production: basic requirements and role of the SYWST motif present in HN cytoplasmic tail. Virology. 2010;405:439-47 pubmed publisher
Sendai virus (SeV) HN protein is dispensable for virus particle production. HN incorporation into virions strictly depends on a cytoplasmic domain SYWST motif...
Krishnan A, Verma S, Mani P, Gupta R, Kundu S, Sarkar D. A histidine switch in hemagglutinin-neuraminidase triggers paramyxovirus-cell membrane fusion. J Virol. 2009;83:1727-41 pubmed publisher
..proteins require coexpression of and activation by a homotypic attachment protein, hemagglutinin-neuraminidase (HN), to promote membrane fusion. However, the molecular mechanism of the activation remains unknown...
A Baumann C, J Neubert W. Neuraminidase-deficient Sendai virus HN mutants provide protection from homologous superinfection. Arch Virol. 2010;155:217-27 pubmed publisher
Binding of hemagglutinin-neuraminidase proteins (HN) to sialylated receptors initiates the infection process of several paramyxoviruses, whereas later in the viral life cycle, the neuramindase (NA) activity of newly synthesized HN ..
Itoh M, Isegawa Y, Hotta H, Homma M. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. J Gen Virol. 1997;78 ( Pt 12):3207-15 pubmed publisher
Bampi C, Rasga L, Roux L. Antagonism to human BST-2/tetherin by Sendai virus glycoproteins. J Gen Virol. 2013;94:1211-9 pubmed publisher
..Suppression of the virus envelope proteins matrix, fusion (F) or haemagglutinin-neuraminidase protein (HN) during the course of infection demonstrates that F and HN, in concert, are responsible for tetherin degradation...
Shevtsova Horoz A, Essaidi Laziosi M, Roux L. Sendai virus particle production: a more detailed role of F and HN through, namely, their association with M. Virus Res. 2015;199:31-41 pubmed publisher
The Paramyxovirus membrane associated proteins are composed of two integral membrane glycoproteins, HN (H, G) and F, and of a matrix protein (M) carpeting the membrane inner layer...