Gene Symbol: nodal
Description: transforming growth factor beta superfamily signaling ligand
Alias: transforming growth factor beta superfamily signaling ligand
Species: sea vase

Top Publications

  1. Mita K, Fujiwara S. Nodal regulates neural tube formation in the Ciona intestinalis embryo. Dev Genes Evol. 2007;217:593-601 pubmed
    ..A similar phenotype was observed in embryos treated with SB431542, an inhibitor of Nodal receptors, suggesting that Ci-Lefty antagonized Nodal signaling as reported in other deuterostome species...
  2. Yoshida K, Saiga H. Repression of Rx gene on the left side of the sensory vesicle by Nodal signaling is crucial for right-sided formation of the ocellus photoreceptor in the development of Ciona intestinalis. Dev Biol. 2011;354:144-50 pubmed publisher
    b>Nodal signaling plays an essential role in the establishment of left-right asymmetry in various animals. However, it is largely unknown how Nodal signaling is involved in the establishment of the left-right asymmetric morphology...
  3. Roure A, Lemaire P, Darras S. An otx/nodal regulatory signature for posterior neural development in ascidians. PLoS Genet. 2014;10:e1004548 pubmed publisher
    ..We report that the combined action of two direct FGF targets, the TGFβ factor Nodal, acting via Smad- and Fox-binding sites, and the transcription factor Otx suffices to trigger ascidian posterior ..
  4. Navarrete I, Levine M. Nodal and FGF coordinate ascidian neural tube morphogenesis. Development. 2016;143:4665-4675 pubmed
    ..Here, we investigate this process in the simple chordate Ciona intestinalis Previous studies have implicated Nodal and FGF signals in the specification of lateral and ventral neural progenitors...