Gene Symbol: brachyury
Description: transcription factor protein
Alias: transcription factor protein
Species: sea vase

Top Publications

  1. Chiba S, Jiang D, Satoh N, Smith W. Brachyury null mutant-induced defects in juvenile ascidian endodermal organs. Development. 2009;136:35-9 pubmed publisher
    ..short-tailed mutant in the ascidian Ciona intestinalis that is the product of a premature stop in the brachyury gene. Notochord differentiation and morphogenesis are severely disrupted in the mutant line...
  2. Dunn M, Di Gregorio A. The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord. Dev Biol. 2009;328:561-74 pubmed publisher
    In Ciona intestinalis, leprecan was identified as a target of the notochord-specific transcription factor Ciona Brachyury (Ci-Bra) (Takahashi, H., Hotta, K., Erives, A., Di Gregorio, A., Zeller, R.W., Levine, M., Satoh, N., 1999...
  3. Passamaneck Y, Katikala L, Perrone L, Dunn M, Oda Ishii I, Di Gregorio A. Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis. Development. 2009;136:3679-89 pubmed publisher
    ..Experiments in ascidian, frog and mouse embryos have shown that co-expression of Brachyury and FoxA class transcription factors is required for notochord development...
  4. Katikala L, Aihara H, Passamaneck Y, Gazdoiu S, José Edwards D, Kugler J, et al. Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord. PLoS Biol. 2013;11:e1001697 pubmed publisher
    ..It is known that the transcription factor Brachyury is required for notochord formation in all chordates, and that it controls transcription of a large number of ..
  5. José Edwards D, Oda Ishii I, Kugler J, Passamaneck Y, Katikala L, Nibu Y, et al. Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord. PLoS Genet. 2015;11:e1005730 pubmed publisher
    ..that most Ciona notochord CRMs relied upon variable combinations of binding sites for the transcription factors Brachyury and/or Foxa2, which can act either synergistically or independently from one another...
  6. Wu Z, Wang K, Wang L, Feng J, Hao S, Tian K, et al. The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population. Int J Mol Sci. 2013;14:21258-65 pubmed publisher
    ..chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk...