Gene Symbol: brachyury
Description: transcription factor protein
Alias: transcription factor protein
Species: sea vase
Chiba S, Jiang D, Satoh N, Smith W. Brachyury null mutant-induced defects in juvenile ascidian endodermal organs. Development. 2009;136:35-9 pubmed publisher
..short-tailed mutant in the ascidian Ciona intestinalis that is the product of a premature stop in the brachyury gene. Notochord differentiation and morphogenesis are severely disrupted in the mutant line...
Dunn M, Di Gregorio A. The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord. Dev Biol. 2009;328:561-74 pubmed publisher
In Ciona intestinalis, leprecan was identified as a target of the notochord-specific transcription factor Ciona Brachyury (Ci-Bra) (Takahashi, H., Hotta, K., Erives, A., Di Gregorio, A., Zeller, R.W., Levine, M., Satoh, N., 1999...
Passamaneck Y, Katikala L, Perrone L, Dunn M, Oda Ishii I, Di Gregorio A. Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis. Development. 2009;136:3679-89 pubmed publisher
..Experiments in ascidian, frog and mouse embryos have shown that co-expression of Brachyury and FoxA class transcription factors is required for notochord development...
Katikala L, Aihara H, Passamaneck Y, Gazdoiu S, José Edwards D, Kugler J, et al
. Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord. PLoS Biol. 2013;11:e1001697 pubmed publisher
..It is known that the transcription factor Brachyury is required for notochord formation in all chordates, and that it controls transcription of a large number of ..
JosÃ© Edwards D, Oda Ishii I, Kugler J, Passamaneck Y, Katikala L, Nibu Y, et al
. Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord. PLoS Genet. 2015;11:e1005730 pubmed publisher
..that most Ciona notochord CRMs relied upon variable combinations of binding sites for the transcription factors Brachyury and/or Foxa2, which can act either synergistically or independently from one another...
Wu Z, Wang K, Wang L, Feng J, Hao S, Tian K, et al
. The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population. Int J Mol Sci. 2013;14:21258-65 pubmed publisher
..chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk...