Gene Symbol: Smp_045200
Description: putative 22.6 kDa tegument antigen
Species: Schistosoma mansoni
Jeffs S, Hagan P, Allen R, Correa Oliveira R, Smithers S, Simpson A. Molecular cloning and characterisation of the 22-kilodalton adult Schistosoma mansoni antigen recognised by antibodies from mice protectively vaccinated with isolated tegumental surface membranes. Mol Biochem Parasitol. 1991;46:159-67 pubmed
..Data are presented which suggest that sm22.6 is a soluble, peripheral membrane protein...
Stein L, David J. Cloning of a developmentally regulated tegument antigen of Schistosoma mansoni. Mol Biochem Parasitol. 1986;20:253-64 pubmed
..Indirect immunofluorescence of adult worms shows this protein to be located in the tegument. ..
Pacifico L, Fonseca C, Chiari L, Oliveira S. Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine. Immunobiology. 2006;211:97-104 pubmed
..Finally, rSm22.6 vaccination induced a Th0 type of immune response and protective immunity that suggests Sm22.6 as a potential candidate to compose an anti-schistosome vaccine. ..
Protasio A, Tsai I, Babbage A, Nichol S, Hunt M, Aslett M, et al
. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1455 pubmed publisher
..schistodb.net) databases. With further transcriptional profiling and genome sequencing increasingly accessible, the upgraded genome will form a fundamental dataset to underpin further advances in schistosome research. ..
Fitzsimmons C, Jones F, Stearn A, Chalmers I, Hoffmann K, Wawrzyniak J, et al
. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Negl Trop Dis. 2012;6:e1593 pubmed publisher
..In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens...