Research Topics

Genomes and Genes

Gene Symbol: phnX

Description: 2-aminoethylphosphonate transport

Species: Salmonella typhimurium LT2

Jiang W, Metcalf W, Lee K, Wanner B. Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. J Bacteriol. 1995;177:6411-21 pubmed

..Complementation studies indicate that the S. typhimurium phn locus probably includes genes both for phosphonate transport and for catalysis of C-P bond cleavage. ..
Baker A, Ciocci M, Metcalf W, Kim J, Babbitt P, Wanner B, et al. Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis. Biochemistry. 1998;37:9305-15 pubmed

..typhimurium enzyme and position 12 in the B. cereusphosphonatase) and last hydrolysis at the imine C(1) and acyl phosphate phosphorus. ..