phnW

Summary

Gene Symbol: phnW
Description: 2-aminoethylphosphonate--pyruvate transaminase
Species: Salmonella typhimurium LT2

Top Publications

  1. Jiang W, Metcalf W, Lee K, Wanner B. Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. J Bacteriol. 1995;177:6411-21 pubmed
    ..Complementation studies indicate that the S. typhimurium phn locus probably includes genes both for phosphonate transport and for catalysis of C-P bond cleavage. ..
  2. Kim A, Baker A, Dunaway Mariano D, Metcalf W, Wanner B, Martin B. The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. J Bacteriol. 2002;184:4134-40 pubmed
    The 2-aminoethylphosphonate transaminase (AEPT; the phnW gene product) of the Salmonella enterica serovar Typhimurium 2-aminoethylphosphonate (AEP) degradation pathway catalyzes the reversible reaction of AEP and pyruvate to form ..
  3. Chen C, Zhang H, Kim A, Howard A, Sheldrick G, Mariano Dunaway D, et al. Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase. Biochemistry. 2002;41:13162-9 pubmed
    ..Modeling of bound substrates and products reveals the structural basis for AEP recognition and the stereospecificity of proton elimination at the alpha-carbon and indicates conformational changes along the reaction pathway...