Gene Symbol: leuO
Description: transcriptional regulator LeuO
Species: Salmonella typhimurium LT2

Top Publications

  1. Fang M, Majumder A, Tsai K, Wu H. ppGpp-dependent leuO expression in bacteria under stress. Biochem Biophys Res Commun. 2000;276:64-70 pubmed publisher
    Despite the known potential transcription regulatory role of leuO gene product, LeuO, the condition when leuO expresses during bacterial growth cycle remains unclear...
  2. Espinosa E, Casadesus J. Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by the LysR-type regulator LeuO. Mol Microbiol. 2014;91:1057-69 pubmed publisher
    b>LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon...
  3. Haughn G, Wessler S, Gemmill R, Calvo J. High A + T content conserved in DNA sequences upstream of leuABCD in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1986;166:1113-7 pubmed
    ..Deletion of the A + T-rich sequences upstream of the E. coli leu operon does not markedly affect the strength of the leu promoter in vivo. ..
  4. Fang M, Wu H. A promoter relay mechanism for sequential gene activation. J Bacteriol. 1998;180:626-33 pubmed
    ..genes are sequentially expressed in a position-dependent manner: the ilvIH promoter (pilvIH) activates a cryptic leuO promoter (pleuO) located between the two divergently arrayed ilvIH and leu-500 promoters...
  5. Chen C, Fang M, Majumder A, Wu H. A 72-base pair AT-rich DNA sequence element functions as a bacterial gene silencer. J Biol Chem. 2001;276:9478-85 pubmed
    We have previously demonstrated that sequential activation of the bacterial ilvIH-leuO-leuABCD gene cluster involves a promoter-relay mechanism...
  6. Chen C, Wu H. LeuO protein delimits the transcriptionally active and repressive domains on the bacterial chromosome. J Biol Chem. 2005;280:15111-21 pubmed
    b>LeuO protein relieves bacterial gene silencer AT8-mediated transcriptional repression as part of a promoter relay mechanism found in the ilvIH-leuO-leuABCD gene cluster...