Gene Symbol: ZIP1
Description: Zip1p
Alias: Zip1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Storlazzi A, Xu L, Schwacha A, Kleckner N. Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc Natl Acad Sci U S A. 1996;93:9043-8 pubmed
    b>Zip1 is a yeast synaptonemal complex (SC) central region component and is required for normal meiotic recombination and crossover interference...
  2. San Segundo P, Roeder G. Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell. 2000;11:3601-15 pubmed
    ..The silencing protein Dot1 (also known as Pch1) is required for checkpoint-mediated pachytene arrest of the zip1 and dmc1 mutants of Saccharomyces cerevisiae...
  3. Mitra N, Roeder G. A novel nonnull ZIP1 allele triggers meiotic arrest with synapsed chromosomes in Saccharomyces cerevisiae. Genetics. 2007;176:773-87 pubmed
    ..The Zip1 protein is a major building block of the SC in Saccharomyces cerevisiae...
  4. Wu H, Burgess S. Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in budding yeast. Curr Biol. 2006;16:2473-9 pubmed
    ..Importantly, ZIP1, encoding the central element of the SC , is required for PCH2-dependent checkpoint activation...
  5. Humphryes N, Leung W, Argunhan B, Terentyev Y, Dvorácková M, Tsubouchi H. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genet. 2013;9:e1003194 pubmed publisher
    ..complex is a novel SC component, functioning to facilitate assembly of the yeast transverse filament protein, Zip1. Ecm11 and Gmc2 initially localize to the synapsis initiation sites, then throughout the synapsed regions of paired ..
  6. Acosta I, Ontoso D, San Segundo P. The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway. Mol Biol Cell. 2011;22:3478-90 pubmed publisher
    ..In the budding yeast zip1 mutant, which lacks a synaptonemal complex component, the meiotic recombination checkpoint is triggered, resulting ..
  7. Leu J, Roeder G. The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28. Mol Cell. 1999;4:805-14 pubmed
    ..The requirement for Swe1 distinguishes the pachytene checkpoint from the DNA damage checkpoints operating in vegetative cells. ..
  8. Bailis J, Smith A, Roeder G. Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol. 2000;20:4838-48 pubmed
    The Saccharomyces cerevisiae zip1 mutant, which exhibits defects in synaptonemal complex formation and meiotic recombination, triggers a checkpoint that causes cells to arrest at the pachytene stage of meiotic prophase...
  9. Börner G, Barot A, Kleckner N. Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc Natl Acad Sci U S A. 2008;105:3327-32 pubmed publisher
    We show that, during budding yeast meiosis, axis ensemble Hop1/Red1 and synaptonemal complex (SC) component Zip1 tend to occur in alternating strongly staining domains...

More Information


  1. Tung K, Roeder G. Meiotic chromosome morphology and behavior in zip1 mutants of Saccharomyces cerevisiae. Genetics. 1998;149:817-32 pubmed
    The yeast Zip1 protein (Zip1p) is a component of the central region of the synaptonemal complex (SC). Zip1p is predicted to form a dimer consisting of a coiled-coil domain flanked by globular domains...
  2. Falk J, Chan A, Hoffmann E, Hochwagen A. A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination. Dev Cell. 2010;19:599-611 pubmed publisher
    ..We traced the loss of centromere pairing to the persistent phosphorylation of the chromosomal protein Zip1 on serine 75...
  3. Wu H, Ho H, Burgess S. Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response. Curr Biol. 2010;20:1707-16 pubmed publisher
    ..We discuss how regulation of pachytene exit by Mek1 or similar kinases could influence checkpoint stringency, which may differ among species and between sexes. ..
  4. Börner G, Kleckner N, Hunter N. Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell. 2004;117:29-45 pubmed
    Yeast mutants lacking meiotic proteins Zip1, Zip2, Zip3, Mer3, and/or Msh5 (ZMMs) were analyzed for recombination, synaptonemal complex (SC), and meiotic progression...
  5. Newnham L, Jordan P, Rockmill B, Roeder G, Hoffmann E. The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I. Proc Natl Acad Sci U S A. 2010;107:781-5 pubmed publisher
    ..We have found that, in budding yeast, a mutation eliminating the synaptonemal complex protein, Zip1, increases the meiosis I nondisjunction rate of nonexchange chromosomes (NECs)...
  6. Refolio E, Cavero S, Marcon E, Freire R, San Segundo P. The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates. J Cell Sci. 2011;124:2488-500 pubmed publisher
    ..Thus, our results point to an evolutionary conserved role for Ddc2/ATRIP in monitoring meiotic chromosome metabolism. ..
  7. Agarwal S, Roeder G. Zip3 provides a link between recombination enzymes and synaptonemal complex proteins. Cell. 2000;102:245-55 pubmed
    ..We speculate that Zip3 is a component of recombination nodules and serves to link the initiation of synapsis to meiotic recombination...
  8. San Segundo P, Roeder G. Pch2 links chromatin silencing to meiotic checkpoint control. Cell. 1999;97:313-24 pubmed
    ..Mutation of PCH2 relieves the checkpoint-induced pachytene arrest of the zip1, zip2, and dmc1 mutants, resulting in chromosome missegregation and low spore viability...
  9. Peoples Holst T, Burgess S. Multiple branches of the meiotic recombination pathway contribute independently to homolog pairing and stable juxtaposition during meiosis in budding yeast. Genes Dev. 2005;19:863-74 pubmed
    ..We suggest that transient, early DSB-initiated interactions, including those that give rise to noncrossovers, are important for homolog recognition and juxtaposition. ..
  10. Ho H, Burgess S. Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis. PLoS Genet. 2011;7:e1002351 pubmed publisher
    ..In addition, Xrs2, like Pch2, is required for checkpoint-mediated delay conferred by the failure to synapse chromosomes...
  11. Tsubouchi T, Roeder G. A synaptonemal complex protein promotes homology-independent centromere coupling. Science. 2005;308:870-3 pubmed
    ..These centromeric interactions depend on the synaptonemal complex component Zip1. During meiosis in wild-type diploids, centromere couples are initially nonhomologous and then undergo switching ..
  12. Xu L, Weiner B, Kleckner N. Meiotic cells monitor the status of the interhomolog recombination complex. Genes Dev. 1997;11:106-18 pubmed
    ..g., pachytene). In yeast, mutations of this type include rad50S, dmc1, rad51, and zip1. Rad50 is likely part of a recombination initiation complex...
  13. Dong H, Roeder G. Organization of the yeast Zip1 protein within the central region of the synaptonemal complex. J Cell Biol. 2000;148:417-26 pubmed
    The yeast Zip1 protein is a component of the central region of the synaptonemal complex (SC). Zip1 is predicted to form an alpha-helical coiled coil, flanked by globular domains at the NH(2) and COOH termini...
  14. Wang Y, Chang C, Wu J, Tung K. Nuclear localization of the meiosis-specific transcription factor Ndt80 is regulated by the pachytene checkpoint. Mol Biol Cell. 2011;22:1878-86 pubmed publisher
    ..The NDT80-bc mutation relieves the checkpoint-mediated arrest of the zip1, dmc1, and hop2 mutants, producing spores with low viability...
  15. Rockmill B, Sym M, Scherthan H, Roeder G. Roles for two RecA homologs in promoting meiotic chromosome synapsis. Genes Dev. 1995;9:2684-95 pubmed
    ..In the zip1 mutant, chromosomes are paired homologously, but not synapsed, and the protein backbones (axial elements) of each ..
  16. Cheng C, Lo Y, Liang S, Ti S, Lin F, Yeh C, et al. SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae. Genes Dev. 2006;20:2067-81 pubmed
    ..In Saccharomyces cerevisiae, the Zip1 protein is the integral component of the SC...
  17. Chuong H, Dawson D. Meiotic cohesin promotes pairing of nonhomologous centromeres in early meiotic prophase. Mol Biol Cell. 2010;21:1799-809 pubmed publisher
    ..In budding yeast, the protein Zip1p is a major component of the central element of the synaptonemal complex in pachytene of meiosis, and earlier, is ..
  18. Ahuja J, Sandhu R, Mainpal R, Lawson C, Henley H, Hunt P, et al. Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome. Science. 2017;355:408-411 pubmed publisher
    ..and regulatory proteasome particles were recruited to chromosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and SC protein Zip1 . We conclude that proteasome functions along meiotic chromosomes are evolutionarily conserved.
  19. Kurdzo E, Obeso D, Chuong H, Dawson D. Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae. Genetics. 2017;205:657-671 pubmed publisher
    ..The synaptonemal complex protein Zip1 is necessary for both types of centromere association...
  20. Ontoso D, Acosta I, van Leeuwen F, Freire R, San Segundo P. Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor. PLoS Genet. 2013;9:e1003262 pubmed publisher
    ..dot1 deletion, H3-K79A or H3-K79R mutations suppress the checkpoint-imposed meiotic delay of a synapsis-defective zip1 mutant...
  21. Serrentino M, Chaplais E, Sommermeyer V, Borde V. Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination. PLoS Genet. 2013;9:e1003416 pubmed publisher
    ..This work shows that DSB hotspots are not necessarily CO hotspots and suggests that different categories of DSB sites may fulfill different functions. ..
  22. Voelkel Meiman K, Taylor L, Mukherjee P, Humphryes N, Tsubouchi H, MacQueen A. SUMO localizes to the central element of synaptonemal complex and is required for the full synapsis of meiotic chromosomes in budding yeast. PLoS Genet. 2013;9:e1003837 pubmed publisher
    ..However, fundamental details of SC architecture and assembly remain poorly understood. The coiled-coil protein, Zip1, is the only component whose arrangement within the mature SC of budding yeast has been extensively characterized...
  23. Voelkel Meiman K, Cheng S, Morehouse S, MacQueen A. Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutS?-Mediated Crossover Formation. Genetics. 2016;203:1091-103 pubmed publisher
    ..For example, budding yeast mutants missing the SC transverse filament component, Zip1, and mutant cells missing the Zip4 protein, which is required for the elaboration of SC, fail to form MutS?-..
  24. Chen X, Suhandynata R, Sandhu R, Rockmill B, Mohibullah N, Niu H, et al. Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol. 2015;13:e1002329 pubmed publisher
    ..the "ZMM" genes, which encode a functionally diverse set of proteins, including the transverse filament protein, Zip1. In wild-type meiosis, Zmm proteins promote the biased resolution of recombination intermediates into crossovers ..
  25. Cavero S, Herruzo E, Ontoso D, San Segundo P. Impact of histone H4K16 acetylation on the meiotic recombination checkpoint in Saccharomyces cerevisiae. Microb Cell. 2016;3:606-620 pubmed publisher
    ..eliminates the delay in meiotic cell cycle progression imposed by the checkpoint in the synapsis-defective zip1 mutant...
  26. Trelles Sticken E, Loidl J, Scherthan H. Increased ploidy and KAR3 and SIR3 disruption alter the dynamics of meiotic chromosomes and telomeres. J Cell Sci. 2003;116:2431-42 pubmed
    ..Comparison of the expression of meiosis-specific Ndj1p-HA and Zip1p in haploid control and kar3Delta time courses revealed that fewer cells enter the meiotic cycle in absence of ..
  27. Vincenten N, Kuhl L, Lam I, Oke A, Kerr A, Hochwagen A, et al. The kinetochore prevents centromere-proximal crossover recombination during meiosis. elife. 2015;4: pubmed publisher
  28. Klutstein M, Xaver M, Shemesh R, Zenvirth D, Klein F, Simchen G. Separation of roles of Zip1 in meiosis revealed in heterozygous mutants of Saccharomyces cerevisiae. Mol Genet Genomics. 2009;282:453-62 pubmed publisher
    ..Mutations in the SC-component gene ZIP1 diminish SC formation, leading to reduced recombination levels and low spore viability...
  29. Herruzo E, Ontoso D, González Arranz S, Cavero S, Lechuga A, San Segundo P. The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects. Nucleic Acids Res. 2016;44:7722-41 pubmed publisher
    ..Meiotic defects resulting from the absence of the synaptonemal complex component Zip1 activate a meiosis-specific checkpoint network resulting in delayed or arrested meiotic progression...
  30. Chan A, Borts R, Hoffmann E. Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast. PLoS ONE. 2009;4:e7284 pubmed publisher
    ..with several other proteins, collectively termed the Synapsis Initiation Complex (SIC) proteins or 'ZMM's (Zip1-Zip2-Zip3-Zip4-Spo16, Msh4-Msh5, Mer3)...
  31. Obeso D, Dawson D. Temporal characterization of homology-independent centromere coupling in meiotic prophase. PLoS ONE. 2010;5:e10336 pubmed publisher
    ..In the absence of the synaptonemal complex component, Zip1, centromere coupling was undetectable, at all times examined, confirming the essential role of this protein on this ..