Gene Symbol: YTA7
Description: Yta7p
Alias: Yta7p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Tackett A, Dilworth D, Davey M, O DONNELL M, Aitchison J, Rout M, et al. Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol. 2005;169:35-47 pubmed
    ..pol epsilon, the Isw2-Itc1 and Top2 chromatin remodeling proteins, the Sas3-Spt16 chromatin modifying complex, and Yta7, a bromodomain-containing AAA ATPase...
  2. Jambunathan N, Martinez A, Robert E, Agochukwu N, Ibos M, Dugas S, et al. Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary. Genetics. 2005;171:913-22 pubmed
    ..key tyrosine residue shown to be important for acetyllysine binding in other bromodomains, we confirmed that a GST-Yta7p bromodomain fusion was capable of binding to histones in vitro...
  3. Gradolatto A, Rogers R, Lavender H, Taverna S, Allis C, Aitchison J, et al. Saccharomyces cerevisiae Yta7 regulates histone gene expression. Genetics. 2008;179:291-304 pubmed publisher
    The Saccharomyces cerevisiae Yta7 protein is a component of a nucleosome bound protein complex that maintains distinct transcriptional zones of chromatin...
  4. Gradolatto A, Smart S, Byrum S, Blair L, Rogers R, Kolar E, et al. A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity. Mol Cell Biol. 2009;29:4604-11 pubmed publisher
    Saccharomyces cerevisiae Yta7 is a barrier active protein that modulates transcriptional states at the silent mating locus, HMR...
  5. Fillingham J, Kainth P, Lambert J, van Bakel H, Tsui K, Pena Castillo L, et al. Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell. 2009;35:340-51 pubmed publisher
    ..acetyltransferase Rtt109 and restriction of Rtt106 to the promoter region by the bromodomain-containing protein Yta7. We propose that the maintenance of Asf1/HIR/Rtt106-mediated repressive chromatin domains is the primary mechanism ..
  6. Lombardi L, Ellahi A, Rine J. Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7. Proc Natl Acad Sci U S A. 2011;108:E1302-11 pubmed publisher
    b>Yta7 is a highly conserved bromodomain-containing protein with AAA-ATPase homology originally implicated in heterochromatin boundary function in Saccharomyces cerevisiae...
  7. Kurat C, Lambert J, van Dyk D, Tsui K, van Bakel H, Kaluarachchi S, et al. Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein. Genes Dev. 2011;25:2489-501 pubmed publisher
    ..regulated by a novel attach-release mechanism involving phosphorylation of the conserved chromatin boundary protein Yta7 by both cyclin-dependent kinase 1 (Cdk1) and casein kinase 2 (CK2)...
  8. Kuranda K, Grabinska K, Berges T, Karst F, Leberre V, Sokol S, et al. The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2009;9:381-90 pubmed publisher
    ..searched for its protein partners using a two-hybrid screen, and identified five interacting proteins, among them Yta7p. Subsequently, we showed that Yta7p was a membrane-associated protein localized both to the nucleus and to the ..
  9. Mattiazzi M, Jambhekar A, Kaferle P, DeRisi J, Krizaj I, Petrovic U. Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape. Mol Genet Genomics. 2010;283:519-30 pubmed publisher

More Information


  1. Cattaneo M, Morozumi Y, Perazza D, Boussouar F, Jamshidikia M, Rousseaux S, et al. Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization. Mol Cells. 2014;37:851-6 pubmed publisher
    ..Studies conducted on the yeast Saccharomyces cerevisiae ATAD2 homologue, Yta7, are now indicating that the members of this family may primarily be regulators of chromatin dynamics and that ..
  2. Agostoni Carbone M, Lucchini G, Melchioretto P, Nardese V, Vanoni M, Panzeri L. A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames. Yeast. 1998;14:587-91 pubmed
    ..It corresponds to the YTA7 gene, a member of a set of yeast genes coding for putative ATPases with high similarity to constituents of the 26S ..
  3. Barrales R, Jimenez J, Ibeas J. Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae. Genetics. 2008;178:145-56 pubmed publisher
    ..In addition to previously characterized activators, we identified a number of novel FLO11 activators, which reveal the pH response pathway and chromatin-remodeling complexes as central elements involved in FLO11 activation. ..
  4. Estruch F, Peiró Chova L, Gómez Navarro N, Durbán J, Hodge C, del Olmo M, et al. A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor. Mol Genet Genomics. 2009;281:125-34 pubmed publisher
    ..Finally, our results also uncovered genetic connections between Mex67p and the poly(A) nuclease complex and with components of chromatin boundary elements. ..
  5. Lombardi L, Davis M, Rine J. Maintenance of nucleosomal balance in cis by conserved AAA-ATPase Yta7. Genetics. 2015;199:105-16 pubmed publisher
    The extent of chromatin compaction is a fundamental driver of nuclear metabolism . Yta7 is a chromatin-associated AAA-ATPase, the human ortholog of which, ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of ..