Genomes and Genes
Gene Symbol: YTA12
Description: m-AAA protease subunit YTA12
Alias: RCA1, m-AAA protease subunit YTA12
Species: Saccharomyces cerevisiae S288c
- Suppanz I, Wurm C, Wenzel D, Jakobs S. The m-AAA protease processes cytochrome c peroxidase preferentially at the inner boundary membrane of mitochondria. Mol Biol Cell. 2009;20:572-80 pubmed publisher..These findings suggest that protein quality control and proteolytic activation exerted by the m-AAA protease take place preferentially in the IBM pointing to significant functional differences between the IBM and the CM. ..
- Lee S, Lee H, Yoo S, Kim H. Molecular insights into the m-AAA protease-mediated dislocation of transmembrane helices in the mitochondrial inner membrane. J Biol Chem. 2017;292:20058-20066 pubmed publisher..hetero-hexameric AAA (ATPase associated with diverse cellular activities) protease, composed of the Yta10 and Yta12 proteins, regulates mitochondrial proteostasis by mediating protein maturation and degradation...
- Tzagoloff A, Yue J, Jang J, Paul M. A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae. J Biol Chem. 1994;269:26144-51 pubmed..These results are most compatible with the idea that the gene defined by G25 mutants (RCA1) codes for a protein essential for the assembly of functional respiratory and ATPase complexes...
- Cottier F, Raymond M, Kurzai O, Bolstad M, Leewattanapasuk W, Jimenez Lopez C, et al. The bZIP transcription factor Rca1p is a central regulator of a novel CO? sensing pathway in yeast. PLoS Pathog. 2012;8:e1002485 pubmed publisher..Rca1p appears to regulate cellular metabolism in response to CO(2) availability in environments as diverse as the phagosome, yeast communities or liquid culture. ..
- Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, Tsai F. Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. J Biol Chem. 2011;286:4404-11 pubmed publisher..Here, we have analyzed the hetero-oligomeric yeast m-AAA protease composed of homologous Yta10 and Yta12 subunits...
- Nolden M, Ehses S, Koppen M, Bernacchia A, Rugarli E, Langer T. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Cell. 2005;123:277-89 pubmed..Our findings therefore rationalize mitochondrial defects associated with m-AAA protease mutants in yeast and shed new light on the mechanism of axonal degeneration in HSP. ..
- Tatsuta T, Model K, Langer T. Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell. 2005;16:248-59 pubmed..Implications of these findings for proposed cellular activities of prohibitins are discussed. ..
- Anghileri P, Branduardi P, Sternieri F, Monti P, Visintin R, Bevilacqua A, et al. Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition. Exp Cell Res. 1999;250:510-23 pubmed..A possible functional antagonism between PKAs and the mitosis promoting factor is also discussed. ..
- Arlt H, Steglich G, Perryman R, Guiard B, Neupert W, Langer T. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. EMBO J. 1998;17:4837-47 pubmed..Deletion of YTA10 or YTA12 impairs degradation of non-assembled inner membrane proteins and assembly of respiratory chain complexes...
- Rep M, Nooy J, Guelin E, Grivell L. Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed. Curr Genet. 1996;30:206-11 pubmed..All three genes also suppressed a null mutation in a related gene, RCA1, as well as in the combination of afg3- and rca1-null.
- Esser K, Tursun B, Ingenhoven M, Michaelis G, Pratje E. A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J Mol Biol. 2002;323:835-43 pubmed..The mAAA protease subunits Yta10 (Afg3) and Yta12 (Rca1) were identified both to be essential for the first processing step...