Gene Symbol: YSC84
Alias: LSB4, Ysc84p
Species: Saccharomyces cerevisiae S288c
Dewar H, Warren D, Gardiner F, Gourlay C, Satish N, Richardson M, et al
. Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:3646-61 pubmed
..Here we demonstrate the importance of two additional cortical components, Ysc84p and Lsb5p, which together are essential for the organization of the actin cytoskeleton and for fluid phase ..
Zarrinpar A, Park S, Lim W. Optimization of specificity in a cellular protein interaction network by negative selection. Nature. 2003;426:676-80 pubmed
..System-wide negative selection is a subtle but powerful evolutionary mechanism to optimize specificity within an interaction network composed of overlapping recognition elements. ..
Landgraf C, Panni S, Montecchi Palazzi L, Castagnoli L, Schneider Mergener J, Volkmer Engert R, et al
. Protein interaction networks by proteome peptide scanning. PLoS Biol. 2004;2:E14 pubmed
..WISE can be easily extended to a variety of protein interaction domains, including those binding to modified peptides, thereby offering a powerful proteomic tool to help completing a full description of the cell interactome. ..
Smaczynska de Rooij I, Costa R, Ayscough K. Yeast Arf3p modulates plasma membrane PtdIns(4,5)P2 levels to facilitate endocytosis. Traffic. 2008;9:559-73 pubmed publisher
..Our data provide evidence for a mechanism in yeast to positively regulate plasma membrane production of PtdIns(4,5)P2 levels and that these changes impact on endocytosis. ..
Madania A, Dumoulin P, Grava S, Kitamoto H, Schärer Brodbeck C, Soulard A, et al
. The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Mol Biol Cell. 1999;10:3521-38 pubmed
Brandina I, Smirnov A, Kolesnikova O, Entelis N, Krasheninnikov I, Martin R, et al
. tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system. FEBS Lett. 2007;581:4248-54 pubmed
..This result suggests a functional link between UPS and tRNA mitochondrial import in yeast and indicates on the existence of negative and positive import regulators. ..
Urbanek A, Allwood E, Smith A, Booth W, Ayscough K. Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis. PLoS ONE. 2015;10:e0136732 pubmed publisher
..In previous studies, Ysc84 was demonstrated to bind actin through a conserved N-terminal domain...
Robertson A, Allwood E, Smith A, Gardiner F, Costa R, Winder S, et al
. The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast. Mol Biol Cell. 2009;20:1618-28 pubmed publisher
..Here, we reveal that the yeast protein Ysc84 represents a new class of actin-binding proteins, conserved from yeast to humans...
Burston H, Maldonado Baez L, Davey M, Montpetit B, Schluter C, Wendland B, et al
. Regulators of yeast endocytosis identified by systematic quantitative analysis. J Cell Biol. 2009;185:1097-110 pubmed publisher
..Our findings highlight the conserved machinery and reveal novel mechanisms that underlie endocytic internalization. ..