Gene Symbol: YRR1
Alias: PDR2, Yrr1p
Species: Saccharomyces cerevisiae S288c
Galdieri L, Desai P, Vancura A. Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator. J Mol Biol. 2012;415:464-74 pubmed publisher
..The separated tail module thus represents a promiscuous transcriptional factor that binds to many different promoters and is necessary for derepression of FLR1 in sin4? cells. ..
Zhang X, Cui Z, Miyakawa T, Moye Rowley W. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J Biol Chem. 2001;276:8812-9 pubmed
..Previous work has identified a novel Cys(6)-Zn(II)(2) transcription factor designated Yrr1p as mutant forms of this protein confer high level resistance to the cell cycle inhibitor reveromycin A and DNA ..
Le Crom S, Devaux F, Marc P, Zhang X, Moye Rowley W, Jacq C. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol. 2002;22:2642-9 pubmed
b>Yrr1p is a recently described Zn(2)Cys(6) transcription factor involved in the pleiotropic drug resistance (PDR) phenomenon. It is controlled in a Pdr1p-dependent manner and is autoregulated...
Akache B, MacPherson S, Sylvain M, Turcotte B. Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem. 2004;279:27855-60 pubmed
..Other zinc cluster activators of multidrug resistance genes include Stb5p and Yrr1p. To better understand the interplay among these activators, we have performed native co-immunoprecipitation ..
Cui Z, Shiraki T, Hirata D, Miyakawa T. Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol Microbiol. 1998;29:1307-15 pubmed
..Northern blot analysis of SNQ2 mRNA levels indicated that Yrr1p is involved in basal and drug-induced transcriptional activation of SNQ2, whereas Pdr1p/Pdr3p transcription ..
Teixeira M, Dias P, Simões T, Sá Correia I. Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1. Biochem Biophys Res Commun. 2008;367:249-55 pubmed
..This activation of FLR1 transcription is fully dependent on Yap1p and is reduced (by 50%) in the absence of Rpn4p, Yrr1p or Pdr3p...
Kodo N, Matsuda T, Doi S, Munakata H. Salicylic acid resistance is conferred by a novel YRR1 mutation in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2013;434:42-7 pubmed publisher
..These results suggested that SA resistance in KinSal052 is conferred by the overexpression of efflux pumps constitutively activated by the mutant form of Yrr1p.
Cui Z, Hirata D, Miyakawa T. Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide. Biosci Biotechnol Biochem. 1999;63:162-7 pubmed
..expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mol. Microbiol., 29, 1307-1315 (1998))...