Gene Symbol: YPI1
Description: type 1 protein phosphatase-activating protein YPI1
Alias: type 1 protein phosphatase-activating protein YPI1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Pedelini L, Marquina M, Arino J, Casamayor A, Sanz L, Bollen M, et al. YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem. 2007;282:3282-92 pubmed
    We have recently characterized Ypi1 as an inhibitory subunit of yeast Glc7 PP1 protein phosphatase...
  2. Bharucha J, Larson J, Gao L, Daves L, Tatchell K. Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1032-45 pubmed publisher
    ..We show here that the budding yeast Ypi1 protein is a nuclear protein that functions with PP1 (Glc7) in this mitotic role...
  3. Tatchell K, Makrantoni V, Stark M, Robinson L. Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proc Natl Acad Sci U S A. 2011;108:3994-9 pubmed publisher
    ..Together, our results suggest that TORC1 positively regulates the Glc7 activity that opposes Ipl1 and provide a mechanism to tie nutritional status with mitotic regulation. ..
  4. Marquina M, González A, Barreto L, Gelis S, Munoz I, Ruiz A, et al. Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin. Genetics. 2012;190:1355-64 pubmed publisher
    b>Ypi1 was discovered as an essential protein able to act as a regulatory subunit of the Saccharomyces cerevisiae type 1 protein phosphatase Glc7 and play a key role in mitosis...
  5. Garcia Gimeno M, Munoz I, Arino J, Sanz P. Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. J Biol Chem. 2003;278:47744-52 pubmed
    ..acid) hydrophilic protein that we identified as a novel, heat-stable inhibitor of type 1 protein phosphatase (Ypi1)...
  6. Tu J, Song W, Carlson M. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:4199-206 pubmed
    ..In addition, this study indicates that the two-hybrid system offers a promising approach to understanding the multiple roles and interactions of PP1 in cellular regulation. ..
  7. Venturi G, Bloecher A, Williams Hart T, Tatchell K. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Genetics. 2000;155:69-83 pubmed
    ..Together our data suggest that Ppz1p and Ppz2p may have overlapping functions with Glc7p and that all three phosphatases may act through common regulatory proteins. ..
  8. Robinson L, Phillips J, Brou L, Boswell E, Tatchell K. Suppressors of ipl1-2 in components of a Glc7 phosphatase complex, Cdc48 AAA ATPase, TORC1, and the kinetochore. G3 (Bethesda). 2012;2:1687-701 pubmed publisher
    ..include three intragenic, second-site revertants in IPL1; 17 mutations in Glc7 phosphatase components (GLC7, SDS22, YPI1); two mutations in SHP1, encoding a regulator of the AAA ATPase Cdc48; and a mutation in TCO89, encoding a subunit ..
  9. Cheng Y, Chen R. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015;128:1180-92 pubmed publisher
    ..Mutation or depletion of the PP1 regulatory subunits Sds22 and Ypi1, which are involved in nuclear targeting of Glc7, also produce Glc7 aggregates, indicating that association with ..

More Information


  1. Marquina M, Queralt E, Casamayor A, Arino J. Lack of the Glc7 phosphatase regulatory subunit Ypi1 activates the morphogenetic checkpoint. Int J Biochem Cell Biol. 2012;44:1862-71 pubmed publisher
    b>Ypi1 is an essential regulator of the Saccharomyces cerevisiae Glc7 protein phosphatase...