YME2

Summary

Gene Symbol: YME2
Description: Yme2p
Alias: PRP12, RNA12, Yme2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Thorsness P, Fox T. Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Genetics. 1993;134:21-8 pubmed
    ..no detectable growth phenotypes, synergistic interactions were observed in two double mutant combinations: a yme1, yme2 double mutant failed to respire at 30 degrees and a yme4, yme6 double mutant failed to respire at all temperatures ..
  2. Hanekamp T, Thorsness P. YNT20, a bypass suppressor of yme1 yme2, encodes a putative 3'-5' exonuclease localized in mitochondria of Saccharomyces cerevisiae. Curr Genet. 1999;34:438-48 pubmed
    ..YNT20p is a soluble mitochondrial protein that belongs to a subfamily of putative 3'-5' exonucleases. Furthermore, conserved sequence elements in Yme2p suggest that this protein may also function as an exonuclease.
  3. Park S, Hanekamp T, Thorsness M, Thorsness P. Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Curr Genet. 2006;50:173-82 pubmed
    ..A specific allele of one of these genes, yme2-4, prevents even the low wild-type rate of mitochondrial DNA transfer to the nucleus and imparts significant ..
  4. Hanekamp T, Thorsness P. Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:2764-71 pubmed
    ..of the synthetic growth defect of yme1 yme2 strains and was found to be identical with the previously cloned RNA12 gene. The dominant temperature-sensitive mutation RNA12-1 prevents growth of yeast cells at 37 degrees C...