YCS4

Summary

Gene Symbol: YCS4
Description: condensin subunit YCS4
Alias: LOC7, condensin subunit YCS4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Haeusler R, Pratt Hyatt M, Good P, Gipson T, Engelke D. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev. 2008;22:2204-14 pubmed publisher
    ..These observations suggest a widespread role for condensin in gene organization and packaging of the interphase yeast nucleus. ..
  2. Freeman L, Aragon Alcaide L, Strunnikov A. The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol. 2000;149:811-24 pubmed
    ..Thus, the rDNA array is the first identified set of DNA sequences specifically bound by condensin in vivo. The biological role of higher-order chromosome structure in S. cerevisiae is discussed. ..
  3. D Amours D, Stegmeier F, Amon A. Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA. Cell. 2004;117:455-69 pubmed
    ..This dual role of the FEAR network in initiating mitotic exit and promoting chromosome segregation ensures that exit from mitosis is coupled to the completion of chromosome segregation. ..
  4. Yu H, Koshland D. Meiotic condensin is required for proper chromosome compaction, SC assembly, and resolution of recombination-dependent chromosome linkages. J Cell Biol. 2003;163:937-47 pubmed
  5. Lavoie B, Hogan E, Koshland D. In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol. 2002;156:805-15 pubmed
    ..Finally, we provide the first evidence of a mechanistic link between condensin and cohesin function. A model discussing the functional interplay between cohesin and condensin is presented. ..
  6. Hirano T. SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates?. Genes Dev. 1999;13:11-9 pubmed
  7. Bhalla N, Biggins S, Murray A. Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol Biol Cell. 2002;13:632-45 pubmed
    The budding yeast YCS4 gene encodes a conserved regulatory subunit of the condensin complex. We isolated an allele of this gene in a screen for mutants defective in sister chromatid separation or segregation...
  8. Lam W, Peterson E, Yeung M, Lavoie B. Condensin is required for chromosome arm cohesion during mitosis. Genes Dev. 2006;20:2973-84 pubmed
    ..We discuss the implications of our results for current models of sister chromatid cohesion. ..
  9. Yong Gonzalez V, Wang B, Butylin P, Ouspenski I, Strunnikov A. Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes Cells. 2007;12:1075-90 pubmed
    ..These findings show that, in addition to its essential role in rDNA segregation, condensin mediates segregation of the whole genome by maintaining the centromere structure in Saccharomyces cerevisiae. ..

More Information

Publications19

  1. Tsang C, Li H, Zheng X. Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 2007;26:448-58 pubmed
    ..Our data suggest that enrichment of condensin prevents rDNA instability during nutrient starvation. Together, these observations unravel a novel role for condensin in the maintenance of regional genomic stability. ..
  2. Li Z, Vizeacoumar F, Bahr S, Li J, Warringer J, Vizeacoumar F, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011;29:361-7 pubmed publisher
    ..This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes. ..
  3. Doughty T, Arsenault H, Benanti J. Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PLoS Genet. 2016;12:e1006216 pubmed publisher
  4. Varela E, Shimada K, Laroche T, Leroy D, Gasser S. Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression. EMBO J. 2009;28:1562-75 pubmed publisher
    ..This may argue that different levels of Cdk inactivation control spindle disassembly and chromatin decompaction. Mutation of lte1 also impaired rotation of the nucleus in early G1. ..
  5. Tsang C, Zheng X. Opposing role of condensin and radiation-sensitive gene RAD52 in ribosomal DNA stability regulation. J Biol Chem. 2009;284:21908-19 pubmed publisher
    ..In contrast, deletion of RAD52 restores cell viability under the same conditions. These results reveal an opposing role of condensin and Rad52 in the control of rDNA stability under nutrient starvation conditions. ..
  6. Gard S, Light W, Xiong B, Bose T, McNairn A, Harris B, et al. Cohesinopathy mutations disrupt the subnuclear organization of chromatin. J Cell Biol. 2009;187:455-62 pubmed publisher
    ..We propose that the cohesin network affects gene regulation by facilitating the subnuclear organization of chromatin. ..
  7. Hong S, Choi E, Kim K. Ycs4 is Required for Efficient Double-Strand Break Formation and Homologous Recombination During Meiosis. J Microbiol Biotechnol. 2015;25:1026-35 pubmed publisher
    ..We demonstrate that Ycs4 is required for efficient DSB formation and establishing homolog bias at the early stage of meiotic prophase I, ..
  8. Markowitz T, Suarez D, Blitzblau H, Patel N, Markhard A, MacQueen A, et al. Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae. PLoS Genet. 2017;13:e1006928 pubmed publisher
    ..Our results indicate separable roles for Red1 in building the structural axis of meiotic chromosomes and mounting a sustained recombination checkpoint response. ..
  9. Li P, Jin H, Yu H. Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast. Mol Biol Cell. 2014;25:2934-47 pubmed publisher
    ..Our work reveals that condensin coordinates meiotic recombination with chromosome segregation at the repetitive rDNA sequence, thereby maintaining genome integrity. ..
  10. Laflamme G, Tremblay Boudreault T, Roy M, Andersen P, Bonneil E, Atchia K, et al. Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity. J Biol Chem. 2014;289:27418-31 pubmed publisher
    ..Collectively, these findings demonstrate that SMC proteins can bind to and stabilize microtubules and that SMC-microtubule interactions are essential to establish a robust system to maintain genome integrity. ..