YCG1

Summary

Gene Symbol: YCG1
Description: condensin subunit YCG1
Alias: TIE1, YCS5, condensin subunit YCG1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Freeman L, Aragon Alcaide L, Strunnikov A. The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol. 2000;149:811-24 pubmed
    ..Thus, the rDNA array is the first identified set of DNA sequences specifically bound by condensin in vivo. The biological role of higher-order chromosome structure in S. cerevisiae is discussed. ..
  2. St Pierre J, Douziech M, Bazile F, Pascariu M, Bonneil E, Sauvé V, et al. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Mol Cell. 2009;34:416-26 pubmed publisher
    ..Our results reveal the existence of a regulatory mechanism essential for the promotion of genome integrity through the stimulation of chromosome condensation in late mitosis. ..
  3. Yu H, Koshland D. Meiotic condensin is required for proper chromosome compaction, SC assembly, and resolution of recombination-dependent chromosome linkages. J Cell Biol. 2003;163:937-47 pubmed
  4. Ouspenski I, Cabello O, Brinkley B. Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell. 2000;11:1305-13 pubmed
    ..Temperature-sensitive mutations of BRN1 can be suppressed by overexpression of a novel gene YCG1, which is homologous to another Xenopus condensin subunit, XCAP-G...
  5. Lavoie B, Hogan E, Koshland D. In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol. 2002;156:805-15 pubmed
    ..Finally, we provide the first evidence of a mechanistic link between condensin and cohesin function. A model discussing the functional interplay between cohesin and condensin is presented. ..
  6. Johzuka K, Horiuchi T. The cis element and factors required for condensin recruitment to chromosomes. Mol Cell. 2009;34:26-35 pubmed publisher
    ..Our study also suggests that recruitment of condensin onto chromosomes requires cis elements and recruiters that physically interact with condensin. ..
  7. Haeusler R, Pratt Hyatt M, Good P, Gipson T, Engelke D. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev. 2008;22:2204-14 pubmed publisher
    ..These observations suggest a widespread role for condensin in gene organization and packaging of the interphase yeast nucleus. ..
  8. D Ambrosio C, Schmidt C, Katou Y, Kelly G, Itoh T, Shirahige K, et al. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev. 2008;22:2215-27 pubmed publisher
    ..This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis...
  9. Li P, Jin H, Yu H. Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast. Mol Biol Cell. 2014;25:2934-47 pubmed publisher
    ..Our work reveals that condensin coordinates meiotic recombination with chromosome segregation at the repetitive rDNA sequence, thereby maintaining genome integrity. ..

More Information

Publications17

  1. Wilson Zbinden C, Dos Santos A, Stoffel Studer I, van der Vaart A, Hofmann K, Reggiori F, et al. Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae. Genetics. 2015;199:475-85 pubmed publisher
  2. Amaral N, Vendrell A, Funaya C, Idrissi F, Maier M, Kumar A, et al. The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Nat Cell Biol. 2016;18:516-26 pubmed publisher
    ..Therefore, the molecular origin of chromatin bridges is critical for activation of NoCut, which plays a key role in the maintenance of genome stability after replicative stress. ..
  3. Lam W, Peterson E, Yeung M, Lavoie B. Condensin is required for chromosome arm cohesion during mitosis. Genes Dev. 2006;20:2973-84 pubmed
    ..We discuss the implications of our results for current models of sister chromatid cohesion. ..
  4. Laflamme G, Tremblay Boudreault T, Roy M, Andersen P, Bonneil E, Atchia K, et al. Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity. J Biol Chem. 2014;289:27418-31 pubmed publisher
    ..Collectively, these findings demonstrate that SMC proteins can bind to and stabilize microtubules and that SMC-microtubule interactions are essential to establish a robust system to maintain genome integrity. ..
  5. Li Z, Vizeacoumar F, Bahr S, Li J, Warringer J, Vizeacoumar F, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011;29:361-7 pubmed publisher
    ..This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes. ..
  6. Hashash N, Johnson A, Cha R. Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis. PLoS Genet. 2012;8:e1002978 pubmed publisher
    ..RSZ breakage, however, required genes encoding condensin subunits (YCG1, YSC4) and topoisomerase II (TOP2)...
  7. Robellet X, Thattikota Y, Wang F, Wee T, Pascariu M, Shankar S, et al. A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division. Genes Dev. 2015;29:426-39 pubmed publisher
    ..Collectively, our results identify the mechanistic basis governing chromosome morphogenesis in early mitosis and how distinct chromatin compaction states can be established via specific thresholds of Cdk1 kinase activity. ..
  8. Doughty T, Arsenault H, Benanti J. Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PLoS Genet. 2016;12:e1006216 pubmed publisher
    ..Here, we demonstrate that Ycg1, the Cap-G subunit of budding yeast condensin, is cell cycle-regulated with levels peaking in mitosis and ..