YAP1

Summary

Gene Symbol: YAP1
Description: DNA-binding transcription factor YAP1
Alias: PAR1, PDR4, SNQ3, DNA-binding transcription factor YAP1
Species: Saccharomyces cerevisiae S288c
Products:     YAP1

Top Publications

  1. Kuge S, Jones N, Nomoto A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 1997;16:1710-20 pubmed
    The YAP1 gene of Saccharomyces cerevisiae encodes a bZIP-containing transcription factor that is essential for the normal response of cells to oxidative stress...
  2. Paulsen C, Carroll K. Chemical dissection of an essential redox switch in yeast. Chem Biol. 2009;16:217-25 pubmed publisher
    ..peroxide in its environment via a redox relay system comprising the thiol peroxidase Gpx3 and transcription factor Yap1. In this signaling pathway, a central unresolved question is whether cysteine sulfenic acid modification of Gpx3 is ..
  3. Alarco A, Balan I, Talibi D, Mainville N, Raymond M. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem. 1997;272:19304-13 pubmed
    ..albicans AP-1. Cap1 and yAP-1 are functional homologues, since CAP1 expression in a yap1 mutant strain partially restores the ability of the cells to grow on toxic concentrations of cadmium or hydrogen ..
  4. Tachibana T, Okazaki S, Murayama A, Naganuma A, Nomoto A, Kuge S. A major peroxiredoxin-induced activation of Yap1 transcription factor is mediated by reduction-sensitive disulfide bonds and reveals a low level of transcriptional activation. J Biol Chem. 2009;284:4464-72 pubmed publisher
    ..b>Yap1, the master transcription factor for the oxidative stress response in budding yeast, is activated by the formation ..
  5. Veal E, Ross S, Malakasi P, Peacock E, Morgan B. Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. J Biol Chem. 2003;278:30896-904 pubmed
    ..Our data indicate that the effects of Ybp1 are mediated through the Yap1 transcription factor...
  6. Okazaki S, Tachibana T, Naganuma A, Mano N, Kuge S. Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal. Mol Cell. 2007;27:675-88 pubmed
    ..The yeast transcription factor Yap1 is activated by disulfide-induced structural changes in the nuclear export signal in a carboxy-terminal domain...
  7. Bouganim N, David J, Wysocki R, Ramotar D. Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression. Biochem Cell Biol. 2001;79:441-8 pubmed
    ..Ycf1 and Acr3 are positively regulated by distinct, but related bZIP transcriptional activators, Yap1 and Yap8, respectively...
  8. Wysocki R, Fortier P, Maciaszczyk E, Thorsen M, Leduc A, Odhagen A, et al. Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p. Mol Biol Cell. 2004;15:2049-60 pubmed
    ..We conclude that Yap1p and Yap8p mediate tolerance by controlling separate subsets of detoxification genes and propose that the two AP-1-like proteins respond to metalloids through distinct mechanisms. ..
  9. Pimentel C, Caetano S, Menezes R, Figueira I, Santos C, Ferreira R, et al. Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2014;1840:1977-86 pubmed publisher
    Cobalt has a rare occurrence in nature, but may accumulate in cells to toxic levels. In the present study, we have investigated how the transcription factor Yap1 mediates tolerance to cobalt toxicity.

More Information

Publications77

  1. Avery A, Willetts S, Avery S. Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance. J Biol Chem. 2004;279:46652-8 pubmed
    ..The Gpx3 (Orp1/PHGpx3) protein transduces the hydroperoxide signal to the transcription factor Yap1, a function that could account for most GPX-dependent phenotypes...
  2. Wiatrowski H, Carlson M. Yap1 accumulates in the nucleus in response to carbon stress in Saccharomyces cerevisiae. Eukaryot Cell. 2003;2:19-26 pubmed
    b>Yap1 is a transcription factor of the AP-1 family that is required for the adaptive response to oxidative stress in Saccharomyces cerevisiae...
  3. Isoyama T, Murayama A, Nomoto A, Kuge S. Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress. J Biol Chem. 2001;276:21863-9 pubmed
    ..Furthermore, we identified the nuclear localization signal of Yap1p and demonstrated that the nuclear import of Yap1p was not affected by oxidative stress. ..
  4. Caetano S, Menezes R, Amaral C, Rodrigues Pousada C, Pimentel C. Repression of the Low Affinity Iron Transporter Gene FET4: A NOVEL MECHANISM AGAINST CADMIUM TOXICITY ORCHESTRATED BY YAP1 VIA ROX1. J Biol Chem. 2015;290:18584-95 pubmed publisher
    ..In the yeast Saccharomyces cerevisiae, the transcription factor Yap1 plays a key role in the regulation of several genes involved in metal stress response...
  5. Menezes R, Amaral C, Batista Nascimento L, Santos C, Ferreira R, Devaux F, et al. Contribution of Yap1 towards Saccharomyces cerevisiae adaptation to arsenic-mediated oxidative stress. Biochem J. 2008;414:301-11 pubmed publisher
    ..In addition, Yap1 is involved in the arsenic adaptation process through regulation of the expression of the vacuolar pump encoded by ..
  6. Galdieri L, Desai P, Vancura A. Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator. J Mol Biol. 2012;415:464-74 pubmed publisher
    ..The separated tail module thus represents a promiscuous transcriptional factor that binds to many different promoters and is necessary for derepression of FLR1 in sin4? cells. ..
  7. Mulford K, Fassler J. Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response. Eukaryot Cell. 2011;10:761-9 pubmed publisher
    ..factors in oxidative stress response promoters and the oxidative stress-sensitive phenotypes of SKN7 and YAP1 mutants suggest that these two factors work together...
  8. Jain C, Yun M, Politz S, Rao R. A pathogenesis assay using Saccharomyces cerevisiae and Caenorhabditis elegans reveals novel roles for yeast AP-1, Yap1, and host dual oxidase BLI-3 in fungal pathogenesis. Eukaryot Cell. 2009;8:1218-27 pubmed publisher
    ..This pathogenesis assay is useful for conducting systematic, whole-genome screens to identify fungal virulence factors as alternative targets for drug development and exploration of host responses to fungal infections. ..
  9. Mason J, Kim S, Knaff D, Wood M. Thermodynamic basis for redox regulation of the Yap1 signal transduction pathway. Biochemistry. 2006;45:13409-17 pubmed
    The Yap1 oxidative stress signal transduction pathway found in Saccharomyces cerevisiae is redox-regulated. We have examined the thermodynamic basis of the disulfide/dithiol couples that are involved in the regulation of this pathway...
  10. Park J, Grant C, Dawes I. The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. Biochem Biophys Res Commun. 2005;327:311-9 pubmed
  11. Tang H, Pan K, Kong K, Hu L, Chan L, Siu K, et al. Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Sci Rep. 2015;5:7897 pubmed publisher
    ..Taken together, our work identified Apd1p as a new ferredoxin which serves critical roles in cellular defense against HU. ..
  12. Stanhill A, Schick N, Engelberg D. The yeast ras/cyclic AMP pathway induces invasive growth by suppressing the cellular stress response. Mol Cell Biol. 1999;19:7529-38 pubmed
    ..In this respect, invasiveness in yeast is reminiscent of the property of ras-transformed fibroblasts to invade soft agar. ..
  13. Na U, Yu W, Cox J, Bricker D, Brockmann K, Rutter J, et al. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab. 2014;20:253-66 pubmed publisher
    ..These studies in yeast and Drosophila raise the possibility that SDHAF3 mutations may be associated with idiopathic SDH-associated diseases. ..
  14. Somboon P, Poonsawad A, Wattanachaisaereekul S, Jensen L, Niimi M, Cheevadhanarak S, et al. Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae. Future Microbiol. 2017;12:417-440 pubmed publisher
    ..Antioxidant regulator Yap1, efflux transporter Pdr5 and ascorbate were pivotal to protect S. cerevisiae from extract cytotoxicity. Xylaria sp...
  15. Zhang C, Li Z, Zhang X, Yuan L, Dai H, Xiao W. Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses. Yeast. 2016;33:5-19 pubmed publisher
    Transcriptomic profiles are generated by comparing wild-type and the yeast yap1 mutant to various chemicals in an attempt to establish a correlation between this gene mutation and chemical exposure...
  16. Fomenko D, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, et al. Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011;108:2729-34 pubmed publisher
    ..The data suggest that thiol peroxidases sense and transfer oxidative signals to the signaling proteins and regulate transcription, whereas a direct interaction between H(2)O(2) and other cellular proteins plays a secondary role. ..
  17. Miyahara K, Hirata D, Miyakawa T. yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet. 1996;29:103-5 pubmed
    ..Of the stresses examined, heat shock-induced, rapid and transient PDR5 expression became very low in a yap1 yap2 double-gene disruptant, indicating that the yAP proteins mediate the response...
  18. Yi D, Kim M, Choi J, Lee J, Jung J, Huh W, et al. Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae. Free Radic Biol Med. 2016;101:424-433 pubmed publisher
    ..In this study, we employed mutant strains lacking Rad51, the homolog of E. coli RecA recombinase, and Yap1 or Skn7, two major transcription factors responsive to ROS, to examine genetic interactions between double-strand ..
  19. Thompson D, Parker R. The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol. 2009;185:43-50 pubmed publisher
    ..Thus, detection of Rny1p, and possibly its orthologues, in the cytosol may be a conserved mechanism for assessing cellular damage and determining cell survival, analogous to the role of cytochrome c as a marker for mitochondrial damage. ..
  20. Gulshan K, Rovinsky S, Moye Rowley W. YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:318-30 pubmed
    ..Together, these data argue that these two homologous proteins act as parallel positive regulators of H2O2 tolerance. ..
  21. Nguyen D, Alarco A, Raymond M. Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. J Biol Chem. 2001;276:1138-45 pubmed
    ..cerevisiae. ..
  22. Scherz R, Shinder V, Engelberg D. Anatomical analysis of Saccharomyces cerevisiae stalk-like structures reveals spatial organization and cell specialization. J Bacteriol. 2001;183:5402-13 pubmed
    ..Colonies grown on 4% agar or higher are reminiscent of stalks in some aspects. The agar concentration effects are mediated in part by the Ras pathway and are related to the invasive-growth phenomenon. ..
  23. Brombacher K, Fischer B, Rüfenacht K, Eggen R. The role of Yap1p and Skn7p-mediated oxidative stress response in the defence of Saccharomyces cerevisiae against singlet oxygen. Yeast. 2006;23:741-50 pubmed
    ..Both, a yap1 and skn7 mutant were highly sensitive to Rose Bengal, an exogenous photosensitizer producing singlet oxygen in the ..
  24. Berra S, Ayachi S, Ramotar D. Upregulation of the Saccharomyces cerevisiae efflux pump Tpo1 rescues an Imp2 transcription factor-deficient mutant from bleomycin toxicity. Environ Mol Mutagen. 2014;55:518-24 pubmed publisher
    ..multicopy suppressors that rescue the imp2? mutant from bleomycin toxicity revealed the transcriptional activator Yap1, which can turn on many target genes such as transporters involved in regulating drug resistance...
  25. He X, Mulford K, Fassler J. Oxidative stress function of the Saccharomyces cerevisiae Skn7 receiver domain. Eukaryot Cell. 2009;8:768-78 pubmed publisher
    ..oxidative stress response genes regulated by Skn7 also are regulated by the redox-responsive transcription factor Yap1. It is therefore possible that the nuclearly localized Skn7 does not itself respond to the oxidant but simply ..
  26. He X, Fassler J. Identification of novel Yap1p and Skn7p binding sites involved in the oxidative stress response of Saccharomyces cerevisiae. Mol Microbiol. 2005;58:1454-67 pubmed
    ..The widespread existence of novel Yap1p and Skn7p binding sites strongly suggest that direct binding of Yap1p and Skn7p is responsible for activation of many more OSR genes than previously believed. ..
  27. Bersweiler A, D Autréaux B, Mazon H, Kriznik A, Belli G, Delaunay Moisan A, et al. A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling. Nat Chem Biol. 2017;13:909-915 pubmed publisher
    In Saccharomyces cerevisiae, Yap1 regulates an H2O2-inducible transcriptional response that controls cellular H2O2 homeostasis...
  28. Ferreira R, Silva A, Pimentel C, Batista Nascimento L, Rodrigues Pousada C, Menezes R. Arsenic stress elicits cytosolic Ca(2+) bursts and Crz1 activation in Saccharomyces cerevisiae. Microbiology. 2012;158:2293-302 pubmed publisher
    ..Here we show that Ca(2+) enhances the tolerance of the wild-type and arsenic-sensitive yap1 strains to arsenic stress in a Crz1-dependent manner, thus providing the first evidence that Ca(2+) signalling ..
  29. Orumets K, Kevvai K, Nisamedtinov I, Tamm T, Paalme T. YAP1 over-expression in Saccharomyces cerevisiae enhances glutathione accumulation at its biosynthesis and substrate availability levels. Biotechnol J. 2012;7:566-8 pubmed publisher
    ..In the present work accumulation of glutathione in response to YAP1 over-expression in Saccharomyces cerevisiae was studied...
  30. Gulshan K, Thommandru B, Moye Rowley W. Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4. J Biol Chem. 2012;287:26796-805 pubmed publisher
    Saccharomyces cerevisiae Yap1 is a transcriptional regulatory protein that serves as a central determinant of oxidative stress tolerance. Activity of this factor is regulated in large part by control of its subcellular location...
  31. Niles B, Joslin A, Fresques T, Powers T. TOR complex 2-Ypk1 signaling maintains sphingolipid homeostasis by sensing and regulating ROS accumulation. Cell Rep. 2014;6:541-52 pubmed publisher
    ..Thus, ROS sensing and signaling by TORC2/Ypk1 play a central physiological role in sphingolipid biosynthesis and in the maintenance of cell growth and viability. ..
  32. Wu A, Wemmie J, Edgington N, Goebl M, Guevara J, Moye Rowley W. Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem. 1993;268:18850-8 pubmed
    ..Overproduction of CAD1 leads to transcriptional activation of an artificial reporter gene in delta yap1 cells...
  33. Zhou J, Zhong Q, Li G, Greenberg M. Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling. J Biol Chem. 2009;284:18106-14 pubmed publisher
    ..These findings show for the first time that perturbation of CL synthesis leads to decreased longevity in yeast, which is restored by altering signaling through stress response pathways. ..
  34. Ramya V, Rajasekharan R. ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae. FEBS Lett. 2016;590:3155-67 pubmed publisher
    ..In vivo and in vitro results showed that Yap1p positively regulates ATG15 expression. Collectively, we demonstrate that Atg15p is a phosphatidylserine lipase and that Yap1p activates the expression of ATG15 during autophagy. ..
  35. Gulshan K, Rovinsky S, Coleman S, Moye Rowley W. Oxidant-specific folding of Yap1p regulates both transcriptional activation and nuclear localization. J Biol Chem. 2005;280:40524-33 pubmed
    ..These data demonstrate that the dually disulfide-bonded Yap1p N- and C-CRDs form a bifunctional protein domain controlling both nuclear localization and transcriptional activation. ..
  36. Maity S, Rajkumar A, Matai L, Bhat A, Ghosh A, Agam G, et al. Oxidative Homeostasis Regulates the Response to Reductive Endoplasmic Reticulum Stress through Translation Control. Cell Rep. 2016;16:851-65 pubmed publisher
    ..Finally, we demonstrate that PERK, a canonical translation attenuator in higher eukaryotes, helps in bypassing a ROS-dependent, non-canonical mode of translation attenuation. ..
  37. Mazzola D, Pimentel C, Caetano S, Amaral C, Menezes R, Santos C, et al. Inhibition of Yap2 activity by MAPKAP kinase Rck1 affects yeast tolerance to cadmium. FEBS Lett. 2015;589:2841-9 pubmed publisher
    ..As a consequence, several Yap2 antioxidant targets are over-activated by a mechanism that also requires Yap1. Several genes of the cell wall integrity (CWI) pathway are upregulated under cadmium stress in a Yap2 dependent ..
  38. Neuber A, Franke J, Wittstruck A, Schlenstedt G, Sommer T, Stade K. Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast. Mol Cell Biol. 2008;28:5348-58 pubmed publisher
    ..In addition, we find a subpopulation of Xpo1 localized at the SPB. Based on these data, we propose a functional link between Xpo1 and the SPB and discuss a role for this exportin in spindle biogenesis in budding yeast. ..
  39. Ma L, Takanishi C, Wood M. Molecular mechanism of oxidative stress perception by the Orp1 protein. J Biol Chem. 2007;282:31429-36 pubmed
    ..Upon exposure to H(2)O(2) Orp1(Cys36) forms a disulfide-bonded complex with the C-terminal domain of the Yap1 protein (Yap1-cCRD)...
  40. Ouyang X, Tran Q, Goodwin S, Wible R, Sutter C, Sutter T. Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses. Free Radic Biol Med. 2011;50:1-13 pubmed publisher
    The yeast Saccharomyces cerevisiae transcription factor Yap1 mediates an adaptive response to oxidative stress by regulating protective genes...
  41. Melber A, Na U, Vashisht A, Weiler B, Lill R, Wohlschlegel J, et al. Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. elife. 2016;5: pubmed publisher
    ..Given these observations, we propose that Nfu1, assisted by Bol3, functions to facilitate Fe-S transfer from the biosynthetic apparatus to the client proteins preventing oxidative damage to [4Fe-4S] clusters. ..
  42. Haugen A, Kelley R, Collins J, Tucker C, Deng C, Afshari C, et al. Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol. 2004;5:R95 pubmed
    ..The highest-scoring proteins included Fhl1, Msn2, Msn4, Yap1, Cad1 (Yap2), Pre1, Hsf1 and Met31...
  43. Van Vranken J, Bricker D, Dephoure N, Gygi S, Cox J, Thummel C, et al. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014;20:241-52 pubmed publisher
    ..These studies provide insights into the mechanisms by which SDH is assembled and raise the possibility that some forms of neuromuscular disease may be associated with mutations that affect this SDH assembly factor. ..
  44. Rowe L, Degtyareva N, Doetsch P. Yap1: a DNA damage responder in Saccharomyces cerevisiae. Mech Ageing Dev. 2012;133:147-56 pubmed publisher
    ..We report a novel, unanticipated role for the transcription factor Yap1 as a DNA damage responder, providing direct evidence that reactive oxygen species are an important component of the ..
  45. Srikanth C, Chakraborti A, Bachhawat A. Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology. 2005;151:99-111 pubmed
    ..In contrast, resistance mediated by Pdr1p/Pdr3p did not require a functional Yap1p, and revealed a distinct hierarchy in the resistance to acetaminophen...
  46. Hirata D, Yano K, Miyakawa T. Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:250-6 pubmed
    ..of 45827 daltons and is homologous in part to a known transcriptional activator protein encoded by YAP1/PDR4/SNQ3/PAR1. Homology was found only in both terminal regions...
  47. Gomar Alba M, del Olmo M. Hot1 factor recruits co-activator Sub1 and elongation complex Spt4/5 to osmostress genes. Biochem J. 2016;473:3065-79 pubmed publisher
    ..Instead, other data presented herein indicate a key function of the Hot1 transcription factor in the recruitment of these proteins to the promoter or the 5'-coding region of the genes under its control. ..
  48. Cordente A, Cordero Bueso G, Pretorius I, Curtin C. Novel wine yeast with mutations in YAP1 that produce less acetic acid during fermentation. FEMS Yeast Res. 2013;13:62-73 pubmed publisher
    ..Specific mutations in YAP1, a gene encoding a transcription factor required for oxidative stress tolerance, were found in three of the four ..
  49. Dejos C, Regnacq M, Bernard M, Voisin P, Berges T. The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast. FEBS Lett. 2013;587:3045-51 pubmed publisher
    Screening for suppressors of canthin-6-one toxicity in yeast identified Yap1, a transcription factor involved in cell response to a broad range of injuries...
  50. Gulshan K, Lee S, Moye Rowley W. Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1. J Biol Chem. 2011;286:34071-81 pubmed publisher
    The Saccharomyces cerevisiae transcription factor Yap1 is a central determinant of oxidative stress tolerance...
  51. Olarewaju O, Ortiz P, Chowdhury W, Chatterjee I, Kinzy T. The translation elongation factor eEF1B plays a role in the oxidative stress response pathway. RNA Biol. 2004;1:89-94 pubmed
    ..As nucleotide exchange is a critical regulator of most G-proteins, these results indicate a new mechanism in the growing list of examples of post-transcriptional responses to cellular stress. ..
  52. Yokoyama H, Mizunuma M, Okamoto M, Yamamoto J, Hirata D, Miyakawa T. Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae. EMBO Rep. 2006;7:519-24 pubmed
    ..We isolated the YAP1 gene as a multicopy suppressor of calcium sensitivity owing to the loss of ZDS1, a negative regulator of SWE1 and ..
  53. Beaufour M, Godin F, Vallee B, Cadene M, Bénédetti H. Interaction proteomics suggests a new role for the Tfs1 protein in yeast. J Proteome Res. 2012;11:3211-8 pubmed publisher
    ..Integration of these results with known functional partners of Tfs1p shows that two subnetworks meet through the Tfs1p node, suggesting that it may act as a bridge between cell signaling and intermediate metabolism in yeast. ..
  54. Altıntaş A, Davidsen K, Garde C, Mortensen U, Brasen J, Sams T, et al. High-resolution kinetics and modeling of hydrogen peroxide degradation in live cells. Free Radic Biol Med. 2016;101:143-153 pubmed publisher
    ..A better fundamental understanding of the role protective factors play in the recovery from oxidative stress may lead to strategies for protecting or sensitizing cell to this stress. ..
  55. Thorsen M, Di Y, Tängemo C, Morillas M, Ahmadpour D, Van der Does C, et al. The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. Mol Biol Cell. 2006;17:4400-10 pubmed
    ..Understanding how arsenite/antimonite uptake and toxicity is modulated may prove of value for their use in medical therapy. ..
  56. Bauer N, Corbett A, Doetsch P. Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn. Traffic. 2013;14:1200-8 pubmed publisher
    ..To validate Q-SCAn, we analyzed relocalization of the transcription factor Yap1 following oxidative stress and then extended the approach to multicompartment localization by examining two DNA ..
  57. Petryk N, Zhou Y, Sybirna K, Mucchielli M, Guiard B, Bao W, et al. Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor. PLoS ONE. 2014;9:e112263 pubmed publisher
    ..Moreover HpHAP4-B is able to complement the H2O2 hypersensitivity of the ScYap1 deletant, YAP1 being, in S. cerevisiae, the main regulator of oxidative stress...
  58. Ilina Y, Sloma E, Maciaszczyk Dziubinska E, Novotny M, Thorsen M, Wysocki R, et al. Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p. Biochem J. 2008;415:467-75 pubmed publisher
    ..We conclude that Yap8p and other yeast AP-1 proteins require distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution. ..
  59. Sugiyama K, Izawa S, Inoue Y. The Yap1p-dependent induction of glutathione synthesis in heat shock response of Saccharomyces cerevisiae. J Biol Chem. 2000;275:15535-40 pubmed
    ..This signal may be mediated by Yap1p, resulting in the elevation of intracellular glutathione levels. ..
  60. Yan C, Lee L, Davis L. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J. 1998;17:7416-29 pubmed
    ..Thus, disassembly of export complexes in response to RanGTP hydrolysis may be required for release of substrate from a terminal binding site at the nuclear pore complex (NPC). ..
  61. Zyrina A, Smirnova E, Markova O, Severin F, Knorre D. Mitochondrial Superoxide Dismutase and Yap1p Act as a Signaling Module Contributing to Ethanol Tolerance of the Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..In agreement with this, the levels of Trx2p and Gsh1p, proteins encoded by Yap1 target genes, were decreased in the absence of Sod2p...
  62. Wu G, Xu Z, Jönsson L. Profiling of Saccharomyces cerevisiae transcription factors for engineering the resistance of yeast to lignocellulose-derived inhibitors in biomass conversion. Microb Cell Fact. 2017;16:199 pubmed publisher
    ..In the presence of complex mixtures of toxic substances from spruce wood, transformants overexpressing YAP1 and STB5, TFs involved in oxidative stress response, exhibited enhanced relative growth rates amounting to 4...
  63. Isoyama T, Kuge S, Nomoto A. The core protein of hepatitis C virus is imported into the nucleus by transport receptor Kap123p but inhibits Kap121p-dependent nuclear import of yeast AP1-like transcription factor in yeast cells. J Biol Chem. 2002;277:39634-41 pubmed
    ..These results suggest that the HCV core protein affects cellular metabolism by disturbing transport of proteins to the nucleus. ..
  64. Robertson J, Davis C, Johnson C. Visible light alters yeast metabolic rhythms by inhibiting respiration. Proc Natl Acad Sci U S A. 2013;110:21130-5 pubmed publisher
    ..Therefore, visible light can modulate cellular rhythmicity and metabolism through unexpectedly photosensitive pathways...
  65. Drobna E, Gazdag Z, Culakova H, Dzugasova V, Gbelska Y, Pesti M, et al. Overexpression of the YAP1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine. FEMS Yeast Res. 2012;12:958-68 pubmed publisher
    ..screening of Saccharomyces cerevisiae genomic library in the high-copy-number plasmid revealed three genes, YAP1, PDE2, and STB3, which increased the CTBT tolerance of the parental strain...
  66. Xu D, Farmer A, Collett G, Grishin N, Chook Y. Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell. 2012;23:3677-93 pubmed publisher
    ..Finally, we also tested CRM1-binding of 40 NESs that were found in the 56 structures. We found that 16 of the NES peptides did not bind CRM1, hence illustrating how NESs are easily misidentified...
  67. Teixeira M, Dias P, Simões T, Sá Correia I. Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1. Biochem Biophys Res Commun. 2008;367:249-55 pubmed
  68. Teixeira M, Cabrito T, Hanif Z, Vargas R, Tenreiro S, Sá Correia I. Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology. 2011;157:945-56 pubmed publisher
    ..to spermine or spermidine dependent on the transcription factors Gcn4, which controls amino acid homeostasis, and Yap1, the main regulator of oxidative stress response...