Gene Symbol: WHI2
Description: Whi2p
Alias: Whi2p
Species: Saccharomyces cerevisiae S288c
Products:     WHI2

Top Publications

  1. Kaida D, Yashiroda H, Toh e A, Kikuchi Y. Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells. 2002;7:543-52 pubmed
    ..This is called the general stress response. The whi2 cells in the stationary phase are smaller than wild-type cells...
  2. Mountain H, Sudbery P. The relationship of growth rate and catabolite repression with WHI2 expression and cell size in Saccharomyces cerevisiae. J Gen Microbiol. 1990;136:733-7 pubmed
    Mixtures of D-glucosamine and glucose were used to slow the growth of wild-type and whi2 mutant strains of Saccharomyces cerevisiae without affecting the level of catabolite repression. The following observations were made...
  3. Jin R, Dobry C, McCown P, Kumar A. Large-scale analysis of yeast filamentous growth by systematic gene disruption and overexpression. Mol Biol Cell. 2008;19:284-96 pubmed
  4. Mendl N, Occhipinti A, Muller M, Wild P, Dikic I, Reichert A. Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J Cell Sci. 2011;124:1339-50 pubmed publisher
    ..initially observed in a ?fis1 mutant was not due to the absence of Fis1 but rather due to a secondary mutation in WHI2, which encodes a factor reported to function in the general stress response and the Ras-protein kinase A (PKA) ..
  5. Sadeh A, Movshovich N, Volokh M, Gheber L, Aharoni A. Fine-tuning of the Msn2/4-mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners. Mol Biol Cell. 2011;22:3127-38 pubmed publisher
    ..Such negative regulation is crucial to minimize the cost of uncontrolled stress response gene expression and ensures a high growth rate in the absence of stress. ..
  6. Chen Y, Stabryla L, Wei N. Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering. Appl Environ Microbiol. 2016;82:2156-2166 pubmed publisher
    ..a genomic-library-based inverse metabolic engineering approach to successfully identify a novel gene target, WHI2 (encoding a cytoplasmatic globular scaffold protein), which elicited improved acetic acid resistance in S...
  7. Radcliffe P, Binley K, Trevethick J, Hall M, Sudbery P. Filamentous growth of the budding yeast Saccharomyces cerevisiae induced by overexpression of the WHi2 gene. Microbiology. 1997;143 ( Pt 6):1867-76 pubmed
    The WHI2 gene of the budding yeast Saccharomyces cerevisiae is required for the arrest of cell proliferation upon nutrient exhaustion: whi2 mutants carry on dividing and in the absence of growth become abnormally small...
  8. Binley K, Radcliffe P, Trevethick J, Duffy K, Sudbery P. The yeast PRS3 gene is required for cell integrity, cell cycle arrest upon nutrient deprivation, ion homeostasis and the proper organization of the actin cytoskeleton. Yeast. 1999;15:1459-69 pubmed
    ..In the same colony-sectoring assay, an mpk1 allele was also recovered. Multicopy PRS3 rescued the caffeine sensitivity of this mpk1 allele. ..
  9. Care A, Vousden K, Binley K, Radcliffe P, Trevethick J, Mannazzu I, et al. A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics. 2004;166:707-19 pubmed

More Information


  1. Leadsham J, Miller K, Ayscough K, Colombo S, Martegani E, Sudbery P, et al. Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast. J Cell Sci. 2009;122:706-15 pubmed publisher
    ..Here, we demonstrate that the loss of Whi2p function, a protein known to influence cell cycle exit under conditions of nutritional stress, leads to cell death ..
  2. Lis P, Jurkiewicz P, Cal BÄ…kowska M, Ko Y, Pedersen P, Goffeau A, et al. Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate. Oncotarget. 2016;7:10153-73 pubmed publisher
    ..Its toxic effect is mainly due to the rapid depletion of intracellular ATP. Moreover, lack of the Whi2p phosphatase results in strongly increased sensitivity of yeast cells to 3-BP, possibly due to the non-functional ..