VPS51

Summary

Gene Symbol: VPS51
Description: Vps51p
Alias: API3, VPS67, WHI6, Vps51p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Conibear E, Stevens T. Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol Biol Cell. 2000;11:305-23 pubmed
    ..The Vps52/53/54 complex joins a growing list of distinct multisubunit complexes that regulate membrane-trafficking events. ..
  2. Reggiori F, Wang C, Stromhaug P, Shintani T, Klionsky D. Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem. 2003;278:5009-20 pubmed
    ..is required for retrograde traffic from the early endosome back to the late Golgi, and for this reason we named it Vps51. This complex participates in a fusion event together with Tlg1 and Tlg2, two SNAREs also shown to be necessary ..
  3. Conibear E, Cleck J, Stevens T. Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. Mol Biol Cell. 2003;14:1610-23 pubmed
    ..Here we show that the Vps52/53/54 complex has an additional subunit, Vps51p. All four members of this tetrameric GARP (Golgi-associated retrograde protein) complex are required for two ..
  4. Fridmann Sirkis Y, Kent H, Lewis M, Evans P, Pelham H. Structural analysis of the interaction between the SNARE Tlg1 and Vps51. Traffic. 2006;7:182-90 pubmed
    ..It consists of four subunits, one of which, Vps51, has been shown to bind specifically to the SNARE Tlg1, which participates in the same fusion event...
  5. Siniossoglou S, Pelham H. Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem. 2002;277:48318-24 pubmed
    ..We show here that the VFT complex contains a fourth, previously uncharacterized, subunit, Vps51p (Ykr020w)...
  6. Gossing M, Chidambaram S, Fischer von Mollard G. Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system. PLoS ONE. 2013;8:e66304 pubmed publisher
    ..As different transport steps were affected our data demonstrate the importance of a folded Vti1p H(abc) domain for transport. ..
  7. Dotiwala F, Eapen V, Harrison J, Arbel Eden A, Ranade V, Yoshida S, et al. DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase. Proc Natl Acad Sci U S A. 2013;110:E41-9 pubmed publisher
    ..Autophagy in response to DNA damage can be induced in three different ways: by deleting the Golgi-associated retrograde protein complex (GARP), by adding rapamycin, or by overexpression of a dominant ATG13-8SA mutation. ..
  8. Fröhlich F, Petit C, Kory N, Christiano R, Hannibal Bach H, Graham M, et al. The GARP complex is required for cellular sphingolipid homeostasis. elife. 2015;4: pubmed publisher
    ..Together, these data show that GARP is essential for cellular sphingolipid homeostasis and suggest a therapeutic strategy for the treatment of PCCA2. ..
  9. Shirahama Noda K, Kira S, Yoshimori T, Noda T. TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy. J Cell Sci. 2013;126:4963-73 pubmed publisher
    ..This clarification of the role of TRAPPIII elucidates how general membrane traffic contributes to autophagy. ..

More Information

Publications17

  1. Ohashi Y, Munro S. Membrane delivery to the yeast autophagosome from the Golgi-endosomal system. Mol Biol Cell. 2010;21:3998-4008 pubmed publisher
    ..This is underestimated by examination of single mutants, providing a possible explanation for discrepancies between yeast and mammalian studies on Atg9 localization and autophagosome formation. ..
  2. Bidlingmaier S, Snyder M. Large-scale identification of genes important for apical growth in Saccharomyces cerevisiae by directed allele replacement technology (DART) screening. Funct Integr Genomics. 2002;1:345-56 pubmed
    ..SMY1, SPA2, PAN1, SLA1, SLA2, CBK1, SEC22, FAB1, VPS36, VID22, RAS2, ECM33, OPI3, API1/YDR372c, API2/YDR525w, API3/YKR020w, and API4/YNL051w), which alter the elongated bud morphology of cdc34-2 cells arrested in the apical growth ..
  3. Eapen V, Haber J. DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression. Autophagy. 2013;9:440-1 pubmed publisher
    ..GARP mutants such as vps51? exhibit mislocalization of the key mitotic regulator, securin (Pds1), and its degradation by the vacuolar ..
  4. Kishimoto T, Yamamoto T, Tanaka K. Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell. 2005;16:5592-609 pubmed
    ..Simultaneous loss of both phospholipid asymmetry and sterol structural integrity could lead to accumulation of endocytic intermediates capable of initiating assembly of actin patches in the cytoplasm. ..
  5. Guo J, Polymenis M. Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep. 2006;7:1124-7 pubmed
    ..Our results are consistent with de-phosphorylation of Ire1 being a mechanism for antagonizing UPR signalling. ..
  6. Bugnicourt A, Froissard M, Sereti K, Ulrich H, Haguenauer Tsapis R, Galan J. Antagonistic roles of ESCRT and Vps class C/HOPS complexes in the recycling of yeast membrane proteins. Mol Biol Cell. 2004;15:4203-14 pubmed
    ..Genetic analyses indicated that these phenotypes were due to the functioning of the Vps class C complex in trafficking both to and from the late endosomal compartment. ..
  7. Bonangelino C, Chavez E, Bonifacino J. Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:2486-501 pubmed
    ..The identification and phenotypic characterization of these novel mutants provide new insights into the mechanisms of vacuolar protein sorting, most notably the probable involvement of the actin cytoskeleton in this process. ..
  8. Chou H, Dukovski D, Chambers M, Reinisch K, Walz T. CATCHR, HOPS and CORVET tethering complexes share a similar architecture. Nat Struct Mol Biol. 2016;23:761-3 pubmed publisher
    ..We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks. ..