Gene Symbol: VPS13
Description: membrane morphogenesis protein VPS13
Alias: SOI1, VPT2, membrane morphogenesis protein VPS13
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Redding K, Brickner J, Marschall L, Nichols J, Fuller R. Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol. 1996;16:6208-17 pubmed
    ..By linkage analysis, the allele-specific suppressors defined three genetic loci, SOI1, S0I2, and S0I3...
  2. Brickner J, Fuller R. SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. J Cell Biol. 1997;139:23-36 pubmed
    ..Isolation of suppressors of the Tyr713Ala mutation in TLS1 previously identified three SOI genes. SOI1, cloned by complementation of a sporulation defect, encodes a novel, hydrophilic 3,144-residue protein with ..
  3. Park J, Okumura Y, Tachikawa H, Neiman A. SPO71 encodes a developmental stage-specific partner for Vps13 in Saccharomyces cerevisiae. Eukaryot Cell. 2013;12:1530-7 pubmed publisher
    ..Proper growth and closure of prospore membranes require the highly conserved Vps13 protein...
  4. Lang A, John Peter A, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol. 2015;210:883-90 pubmed publisher
    ..Here, we identified single amino acid substitutions in Vps13 (vacuolar protein sorting 13), a large universally conserved eukaryotic protein, which suppress all measured ..
  5. Xue Y, Schmollinger S, Attar N, Campos O, Vogelauer M, Carey M, et al. Endoplasmic reticulum-mitochondria junction is required for iron homeostasis. J Biol Chem. 2017;292:13197-13204 pubmed publisher
    ..A mutation in the vacuolar protein sorting 13 (VPS13) gene that rescues the glycolytic phenotype of ERMES mutants suppresses the iron deficiency response and iron ..
  6. Parodi E, Roesner J, Huang L. SPO73 and SPO71 Function Cooperatively in Prospore Membrane Elongation During Sporulation in Saccharomyces cerevisiae. PLoS ONE. 2015;10:e0143571 pubmed publisher
    ..previously been shown to be required for prospore membrane development, along with the constitutively expressed Vps13 involved in vacuolar sorting...
  7. Park J, Thorsness M, Policastro R, McGoldrick L, Hollingsworth N, Thorsness P, et al. Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites. Mol Biol Cell. 2016;27:2435-49 pubmed publisher
    The Vps13 protein family is highly conserved in eukaryotic cells. Mutations in human VPS13 genes result in a variety of diseases, such as chorea acanthocytosis (ChAc), but the cellular functions of Vps13 proteins are not well defined...
  8. Rzepnikowska W, Flis K, Kaminska J, Grynberg M, Urbanek A, Ayscough K, et al. Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate. Hum Mol Genet. 2017;26:1497-1510 pubmed publisher
    ..Yeast Vps13 is involved in vacuolar protein transport and, like hVps13A, participates in PI4P metabolism...
  9. Eguez L, Chung Y, Kuchibhatla A, Paidhungat M, Garrett S. Yeast Mn2+ transporter, Smf1p, is regulated by ubiquitin-dependent vacuolar protein sorting. Genetics. 2004;167:107-17 pubmed
    ..Because Smf1p is ubiquitinated in vivo, we propose that Smf1p is targeted to the vacuole for degradation by ubiquitination-dependent protein sorting. ..

More Information


  1. Dembowski J, Ramesh M, McManus C, Woolford J. Identification of the binding site of Rlp7 on assembling 60S ribosomal subunits in Saccharomyces cerevisiae. RNA. 2013;19:1639-47 pubmed publisher
    ..Thus, we propose that Rlp7 coevolved with these RNA elements to facilitate eukaryotic-specific functions in ribosome assembly and pre-rRNA processing. ..
  2. Kilmartin J. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. J Cell Biol. 2003;162:1211-21 pubmed
    ..The centrosomal human protein containing Sfi1 repeats also binds centrin in the repeat region, showing that this centrin-binding motif is conserved. ..
  3. Park J, Neiman A. VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae. J Cell Sci. 2012;125:3004-11 pubmed publisher
    ..and Cohen syndrome are caused by mutations in different members of a family of genes that are orthologs of yeast VPS13. In vegetatively growing yeast, VPS13 is involved in the delivery of proteins to the vacuole...
  4. John Peter A, Herrmann B, Antunes D, Rapaport D, Dimmer K, Kornmann B. Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites. J Cell Biol. 2017;216:3219-3229 pubmed publisher
    ..Defects in ERMES can, however, be bypassed by point mutations in the endosomal protein Vps13 or by overexpression of the mitochondrial protein Mcp1. How this bypass operates remains unclear...
  5. Luo W, Chang A. Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant. J Cell Biol. 1997;138:731-46 pubmed
    ..Thus, cell surface delivery of mutant Pma1 can occur as a consequence of disturbances at several different sites in the endosomal system. ..
  6. De M, Oleskie A, Ayyash M, Dutta S, Mancour L, Abazeed M, et al. The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion. J Cell Biol. 2017;216:425-439 pubmed publisher
    Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine...