Genomes and Genes
Gene Symbol: VMA16
Description: H(+)-transporting V0 sector ATPase subunit c''
Alias: PPA1, H(+)-transporting V0 sector ATPase subunit c''
Species: Saccharomyces cerevisiae S288c
- Powell B, Graham L, Stevens T. Molecular characterization of the yeast vacuolar H+-ATPase proton pore. J Biol Chem. 2000;275:23654-60 pubmed..Structural differences within the membrane-spanning domains of both V(0) and F(0) may account for the unique properties of the ATP-hydrolyzing V-ATPase compared with the ATP-generating F-type ATP synthase. ..
- Ryan M, Graham L, Stevens T. Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum. Mol Biol Cell. 2008;19:5131-42 pubmed publisher..Our results suggest Voa1p functions with Vma21p early in V(0) assembly in the ER, but then it dissociates before exit of the V(0)-Vma21p complex from the ER for transport to the Golgi compartment. ..
- Diepholz M, Venzke D, Prinz S, Batisse C, Flörchinger B, Rössle M, et al. A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly. Structure. 2008;16:1789-98 pubmed publisher..However, the relative arrangement of the EG and C subunits in solution is more open than that in the holoenzyme, suggesting a conformational change of EGC during regulatory assembly and disassembly. ..
- Ligr M, Velten I, Frohlich E, Madeo F, Ledig M, Fröhlich K, et al. The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast. Mol Biol Cell. 2001;12:2422-32 pubmed..Conversely, Stm1 accumulation induces cell death. In addition we identified five other genes whose overexpression in proteasomal mutants caused similar apoptotic phenotypes. ..