Gene Symbol: VIP1
Description: inositol polyphosphate kinase VIP1
Alias: inositol polyphosphate kinase VIP1
Species: Saccharomyces cerevisiae S288c
Mulugu S, Bai W, Fridy P, Bastidas R, Otto J, Dollins D, et al
. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science. 2007;316:106-9 pubmed
..We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes...
Szijgyarto Z, Garedew A, Azevedo C, Saiardi A. Influence of inositol pyrophosphates on cellular energy dynamics. Science. 2011;334:802-5 pubmed publisher
..Metabolic reprogramming through inositol pyrophosphates is an evolutionary conserved mechanism that is also preserved in mammalian systems...
Lin H, Fridy P, Ribeiro A, Choi J, Barma D, Vogel G, et al
. Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem. 2009;284:1863-72 pubmed publisher
..and Vogel, G. (1996) Biochem. J. 315, 715-725 ). Our study brings us closer to the goal of understanding the structure/function relationships that control specificity in the synthesis and biological actions of inositol pyrophosphates...
Osada S, Kageyama K, Ohnishi Y, Nishikawa J, Nishihara T, Imagawa M. Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae. Mol Biol Rep. 2012;39:4989-96 pubmed publisher
..Several factors are specifically associated with Asf1p, including Vip1p. VIP1 is conserved from yeast to humans and encodes inositol hexakisphoshate and inositol heptakisphosphate kinase...
Steidle E, Chong L, Wu M, Crooke E, Fiedler D, Resnick A, et al
. A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE Î²-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5). J Biol Chem. 2016;291:6772-83 pubmed publisher
..We conclude that Siw14 is a physiological phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7isoform 5PP-IP5to IP6. ..