Gene Symbol: VID24
Description: glucose-induced degradation complex subunit VID24
Alias: GID4, glucose-induced degradation complex subunit VID24
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Regelmann J, Schüle T, Josupeit F, Horak J, Rose M, Entian K, et al. Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell. 2003;14:1652-63 pubmed
    ..The influence of Ubp14p, a deubiquitinating enzyme, on proteasome-dependent catabolite degradation was further uncovered. ..
  2. Chiang M, Chiang H. Vid24p, a novel protein localized to the fructose-1, 6-bisphosphatase-containing vesicles, regulates targeting of fructose-1,6-bisphosphatase from the vesicles to the vacuole for degradation. J Cell Biol. 1998;140:1347-56 pubmed
    ..The VID24 gene was identified by complementation of the FBPase degradation defect of the vid24-1 mutant...
  3. Brown C, Wolfe A, Cui D, Chiang H. The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation. J Biol Chem. 2008;283:26116-27 pubmed publisher
    ..Taken together, our results indicate a strong connection between the Vid trafficking pathway and the endocytic pathway. ..
  4. Menssen R, Schweiggert J, Schreiner J, Kusevic D, Reuther J, Braun B, et al. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem. 2012;287:25602-14 pubmed publisher
    ..Upon the addition of glucose the regulatory subunit Gid4/Vid24 appears, binds to the Gid complex, and triggers ubiquitination of fructose-1,6-bisphosphatase...
  5. Giardina B, Dunton D, Chiang H. Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. J Biol Chem. 2013;288:11636-48 pubmed publisher
    ..We suggest that the ARM domain is required for the association of Vid vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. ..
  6. Hung G, Brown C, Wolfe A, Liu J, Chiang H. Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events. J Biol Chem. 2004;279:49138-50 pubmed
    ..By contrast, the cAMP-dependent signaling pathway was not involved in the non-vacuolar degradation of these proteins, although the phosphorylation of glucose was required. ..
  7. Brown C, Dunton D, Chiang H. The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation. J Biol Chem. 2010;285:1516-28 pubmed publisher
    ..Following the fusion of endosomes with the vacuole, cargo proteins are then degraded in the vacuole. ..
  8. Chen S, Wu X, Wadas B, Oh J, Varshavsky A. An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science. 2017;355: pubmed publisher
    ..We found that the Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, ..
  9. Winters C, Hong Brown L, Chiang H. The Shape of Vesicle-Containing Organelles Is Critical for Their Functions in Vesicle Endocytosis. DNA Cell Biol. 2017;36:909-921 pubmed publisher
    ..We conclude that the shape of vesicle-containing organelles is critical for their functions in vesicle endocytosis...

More Information


  1. Brown C, Liu J, Hung G, Carter D, Cui D, Chiang H. The Vid vesicle to vacuole trafficking event requires components of the SNARE membrane fusion machinery. J Biol Chem. 2003;278:25688-99 pubmed
    ..In contrast, the t-SNARE Vam3p was a necessary vacuolar component. Vid vesicle-vacuole trafficking exhibits characteristics similar to heterotypic membrane fusion events. ..
  2. Pitre S, Dehne F, Chan A, Cheetham J, Duong A, Emili A, et al. PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics. 2006;7:365 pubmed
    ..The data also suggests that a finite set of short polypeptide signals seem to be responsible for the majority of the yeast protein-protein interactions. ..
  3. Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, et al. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell. 2008;19:3323-33 pubmed publisher
    ..Six Gid proteins are present in gluconeogenic cells. A seventh protein, Gid4/Vid24, occurs upon glucose addition to gluconeogenic cells and is afterwards eliminated...