VHS3

Summary

Gene Symbol: VHS3
Description: phosphopantothenoylcysteine decarboxylase complex subunit VHS3
Alias: YOR29-05, phosphopantothenoylcysteine decarboxylase complex subunit VHS3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Tatusov R, Galperin M, Natale D, Koonin E. The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res. 2000;28:33-6 pubmed
    ..The COG database is accompanied by the COGNITOR program that is used to fit new proteins into the COGs and can be applied to functional and phylogenetic annotation of newly sequenced genomes. ..
  2. Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
    ..The possible relationship between the known functions of these suppressor genes and the progress through the G(1)-S transition is discussed. ..
  3. Ruiz A, Munoz I, Serrano R, González A, Simon E, Arino J. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem. 2004;279:34421-30 pubmed
    The yeast gene VHS3 (YOR054c) has been recently identified as a multicopy suppressor of the G(1)/S cell cycle blockade of a conditional sit4 and hal3 mutant...
  4. Stirling P, Srayko M, Takhar K, Pozniakovsky A, Hyman A, Leroux M. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Mol Biol Cell. 2007;18:2336-45 pubmed
    ..Our data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. ..
  5. Ruiz A, González A, Munoz I, Serrano R, Abrie J, Strauss E, et al. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009;5:920-8 pubmed publisher
    ..Sequence homology analyses suggest three candidates-Ykl088w, Hal3 and Vhs3-as putative PPCDC enzymes in Saccharomyces cerevisiae...
  6. Abrie J, González A, Strauss E, Arino J. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3. Biochem J. 2012;442:357-68 pubmed publisher
    ..Taken together, our work highlights specific structural determinants that could be exploited for full understanding of Hal3's cellular functions. ..
  7. González A, Casado C, Petrezselyova S, Ruiz A, Arino J. Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Fungal Genet Biol. 2013;53:1-9 pubmed publisher
    ..Hal3 and Vhs3 are moonlighting proteins acting in Saccharomyces cerevisiae both as inhibitors of the Ppz protein phosphatases and ..
  8. Olzhausen J, Moritz T, Neetz T, Schüller H. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2013;13:565-73 pubmed publisher
    ..In addition, nonessential genes SIS2 and VHS3 similar to CAB3 are also involved...
  9. Makanae K, Kintaka R, Makino T, Kitano H, Moriya H. Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method. Genome Res. 2013;23:300-11 pubmed publisher
    ..The results obtained in this study will provide basic knowledge about the physiology of chromosomal abnormalities and the evolution of chromosomal composition. ..

More Information

Publications10

  1. Abrie J, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015;5:15774 pubmed publisher
    Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopantothenoylcysteine ..