Gene Symbol: VAS1
Description: valine--tRNA ligase
Alias: valine--tRNA ligase
Species: Saccharomyces cerevisiae S288c
Freist W, von der Haar F, Faulhammer H, Cramer F. Valyl-tRNA, isoleucyl-tRNA and tyrosyl-tRNA synthetase from baker's yeast. Substrate specificity with regard to ATP analogs and mechanism of the aminoacylation reaction. Eur J Biochem. 1976;66:493-7 pubmed
..Their Km and Ki and V values have been determined. The substrate specificity shows that positions 2, 6, 7, 8, 9, 2', and 3' of ATP are important for catalytic action of these aminoacyl-tRNA synthetases. ..
Jordana X, Chatton B, Paz Weisshaar M, Buhler J, Cramer F, Ebel J, et al
. Structure of the yeast valyl-tRNA synthetase gene (VASI) and the homology of its translated amino acid sequence with Escherichia coli isoleucyl-tRNA synthetase. J Biol Chem. 1987;262:7189-94 pubmed
Chiu W, Chang C, Wen W, Wang S, Wang C. Schizosaccharomyces pombe possesses two paralogous valyl-tRNA synthetase genes of mitochondrial origin. Mol Biol Evol. 2010;27:1415-24 pubmed publisher
Previous studies showed that VAS1 of Saccharomyces cerevisiae encodes both cytosolic and mitochondrial forms of valyl-tRNA synthetase (ValRS) through alternative initiation of translation...
Francisci S, Montanari A, DE Luca C, Frontali L. Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes. Mitochondrion. 2011;11:919-23 pubmed publisher
..In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects. ..
Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C, De Virgilio C. Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell. 2012;46:105-10 pubmed publisher
..Thus, the EGOC-TORC1 signaling module samples, via the LeuRS-intrinsic editing domain, the fidelity of tRNA(Leu) aminoacylation as a proxy for leucine availability. ..
Chatton B, Walter P, Ebel J, Lacroute F, Fasiolo F. The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases. J Biol Chem. 1988;263:52-7 pubmed
S1 mapping on the VAS1 structural gene indicates the existence of two classes of transcripts initiating at distinct in-frame translation start codons...
Montanari A, DE Luca C, Di Micco P, Morea V, Frontali L, Francisci S. Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle. RNA. 2011;17:1983-96 pubmed publisher
..This allows us to extend to the tRNA(Ile) mutants the cross-suppression activity of aminoacyl-tRNA synthetases previously demonstrated for tRNA(Leu) and tRNA(Val) mutants. ..