Gene Symbol: VAR1
Description: mitochondrial 37S ribosomal protein VAR1
Alias: mitochondrial 37S ribosomal protein VAR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Butow R, Zhu H, Perlman P, Conrad Webb H. The role of a conserved dodecamer sequence in yeast mitochondrial gene expression. Genome. 1989;31:757-60 pubmed
    ..One contains a deletion of the dodecamer at the end of the var1 gene, and the other contains two adjacent transversions in the dodecamer at the end of the reading frame of fit1, a ..
  2. de Zamaroczy M, Bernardi G. The primary structure of the mitochondrial genome of Saccharomyces cerevisiae--a review. Gene. 1986;47:155-77 pubmed
  3. Hudspeth M, Ainley W, Shumard D, Butow R, Grossman L. Location and structure of the var1 gene on yeast mitochondrial DNA: nucleotide sequence of the 40.0 allele. Cell. 1982;30:617-26 pubmed
    Alleles of the var1 locus on yeast mitochondrial DNA specify the size of var1 ribosomal protein. We report the nucleotide sequence of a var1 allele that determines the smallest var1 protein...
  4. Sanchirico M, Fox T, Mason T. Accumulation of mitochondrially synthesized Saccharomyces cerevisiae Cox2p and Cox3p depends on targeting information in untranslated portions of their mRNAs. EMBO J. 1998;17:5796-804 pubmed
    ..DNA sequences specifying these chimeric mRNAs were inserted into mtDNA at the VAR1 locus and expressed in strains containing a nuclearly localized plasmid that supplies a functional form of Var1p, ..
  5. Foury F, Roganti T, Lecrenier N, Purnelle B. The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett. 1998;440:325-31 pubmed
    ..Our data suggest that shuffling of mobile elements plays an important role in the remodelling of the yeast mitochondrial genome. ..
  6. Hell K, Neupert W, Stuart R. Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA. EMBO J. 2001;20:1281-8 pubmed
    ..Taken together, we conclude that the Oxa1 complex represents a general membrane protein insertion machinery in the inner membrane of mitochondria. ..
  7. Saveanu C, Fromont Racine M, Harington A, Ricard F, Namane A, Jacquier A. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. J Biol Chem. 2001;276:15861-7 pubmed
    ..Another newly identified ribosomal protein, Ygl129c, was previously shown to be a member of the DAP-3 family of mitochondrial apoptosis mediators. ..
  8. McStay G, Su C, Tzagoloff A. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. FEBS Lett. 2013;587:943-9 pubmed publisher
  9. Litvinchuk A, Sokolov S, Rogov A, Markova O, Knorre D, Severin F. Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions. Eur J Cell Biol. 2013;92:169-74 pubmed publisher
    ..translation) prevents the loss in control cells but not in the ones expressing mitochondrially-encoded protein Var1 in the nucleus...

More Information


  1. Zassenhaus H, Perlman P. Respiration deficient mutants in the A+T-rich region on yeast mitochondrial DNA containing the var1 gene. Curr Genet. 1982;6:179-88 pubmed publisher
    Several mit mutants mapping within or near the var1 determinant region have been characterized genetically and biochemically...
  2. Davis S, Ellis S. Incorporation of the yeast mitochondrial ribosomal protein Mrp2 into ribosomal subunits requires the mitochondrially encoded Var1 protein. Mol Gen Genet. 1995;247:379-86 pubmed
    ..The mitochondrial genome of S. cerevisiae encodes two components of the small ribosomal subunit, 15S rRNA and the Var1 protein, both of which are necessary for the formation of mature 37S subunits...
  3. Herrmann J, Stuart R, Craig E, Neupert W. Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA. J Cell Biol. 1994;127:893-902 pubmed
    ..In particular, we show that mt-Hsp70 acts in maintaining the var1 protein, the only mitochondrially encoded subunit of mitochondrial ribosomes, in an assembly competent state, ..
  4. Fontanesi F, SOTO I, Horn D, Barrientos A. Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis. Mol Cell Biol. 2010;30:245-59 pubmed publisher
    ..We conclude that Ssc1, by interacting with Mss51 and Mss51-containing complexes, plays a critical role in Cox1 biogenesis, COX assembly, and the translational regulation of these processes. ..