Gene Symbol: VAC7
Species: Saccharomyces cerevisiae S288c
Bonangelino C, Catlett N, Weisman L. Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol Cell Biol. 1997;17:6847-58 pubmed
..VAC7 encodes a novel 128-kDa protein that is localized at the vacuole membrane. This location of Vac7p is consistent with its involvement in vacuole morphology and inheritance.
Rudge S, Anderson D, Emr S. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell. 2004;15:24-36 pubmed
..Genetic studies have indicated that Fab1 kinase is positively regulated by Vac7 and Vac14; deletion of either gene results in ablation of PtdIns(3,5)P2 synthesis and the formation of a grossly ..
Zurita Martinez S, Puria R, Pan X, Boeke J, Cardenas M. Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics. 2007;176:2139-50 pubmed
Efe J, Botelho R, Emr S. Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Mol Biol Cell. 2007;18:4232-44 pubmed
..tandem fusion) construct localizes to the vacuole membrane in the absence of PtdIns(3,5)P(2), but requires Vac7p for recruitment...
Jin N, Chow C, Liu L, Zolov S, Bronson R, Davisson M, et al
. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008;27:3221-34 pubmed publisher
..for the PI(3,5)P(2) regulatory complex by direct contact with the known regulators of PI(3,5)P(2): Fig4, Fab1, Vac7 and Atg18...
Gary J, Sato T, Stefan C, Bonangelino C, Weisman L, Emr S. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell. 2002;13:1238-51 pubmed
..b>VAC7 encodes a 128-kDa transmembrane protein that localizes to vacuolar membranes...
Jin N, Mao K, Jin Y, Tevzadze G, Kauffman E, Park S, et al
. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell. 2014;25:1171-85 pubmed publisher
..These findings reveal PI(3,5)P(2) as a general regulator of TORC1 and suggest that PI(3,5)P(2) provides a platform for TORC1 signaling from lysosomes. ..
Jin N, Jin Y, Weisman L. Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome. J Cell Biol. 2017;216:2075-2090 pubmed publisher