Gene Symbol: UTP8
Species: Saccharomyces cerevisiae S288c
Gallagher J, Dunbar D, Granneman S, Mitchell B, Osheim Y, Beyer A, et al
. RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev. 2004;18:2506-17 pubmed
..This association may thus represent an early step in the formation of the SSU processome. Our results indicate that rRNA transcription and pre-rRNA processing are coordinated via specific components of the SSU processome. ..
Pérez Fernández J, Roman A, De Las Rivas J, Bustelo X, Dosil M. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol. 2007;27:5414-29 pubmed
..Together, our data identify the mechanism of assembly of the 90S preribosome and offer novel information about its internal architecture. ..
Steiner Mosonyi M, Leslie D, Dehghani H, Aitchison J, Mangroo D. Utp8p is an essential intranuclear component of the nuclear tRNA export machinery of Saccharomyces cerevisiae. J Biol Chem. 2003;278:32236-45 pubmed
..One of the proteins identified by this strategy is Utp8p, an essential 80-kDa nucleolar protein that has been implicated in 18 S ribosomal RNA biogenesis...
Ranish J, Hahn S, Lu Y, Yi E, Li X, Eng J, et al
. Identification of TFB5, a new component of general transcription and DNA repair factor IIH. Nat Genet. 2004;36:707-13 pubmed
..The identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease. ..
Bernstein K, Granneman S, Lee A, Manickam S, Baserga S. Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis. Mol Cell Biol. 2006;26:1195-208 pubmed
..In addition, we found that yeasts disrupted in expression of the two nonessential RNA helicases, Dbp3 and Dbp7, grew worse than when either one alone was disrupted. ..
Eswara M, McGuire A, Pierce J, Mangroo D. Utp9p facilitates Msn5p-mediated nuclear reexport of retrograded tRNAs in Saccharomyces cerevisiae. Mol Biol Cell. 2009;20:5007-25 pubmed publisher
..Utp9p is a nucleolar protein that is part of a subcomplex containing several U3 snoRNA-associated proteins including Utp8p, which is a protein that shuttles aminoacyl-tRNAs from the nucleolus to the nuclear tRNA export receptors Los1p ..
Freed E, Baserga S. The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Nucleic Acids Res. 2010;38:4798-806 pubmed publisher
..A protein-protein interaction map of the seven-protein t-Utp subcomplex of which Utp4 is a member shows that Utp8 interacts with the C-terminus of Utp4 and that this interaction is essential for assembly of the SSU processome and ..
McGuire A, Keates R, Cook S, Mangroo D. Structural modeling identified the tRNA-binding domain of Utp8p, an essential nucleolar component of the nuclear tRNA export machinery of Saccharomyces cerevisiae. Biochem Cell Biol. 2009;87:431-43 pubmed publisher
b>Utp8p is an essential 80 kDa intranuclear tRNA chaperone that transports tRNAs from the nucleolus to the nuclear tRNA export receptors in Saccharomyces cerevisiae...
Huang Y, Tseng S, Tsai H, Lenzmeier B, Teng S. Direct interaction between Utp8p and Utp9p contributes to rRNA processing in budding yeast. Biochem Biophys Res Commun. 2010;393:297-302 pubmed publisher
..In this study we demonstrate that two essential components of the SSU processome, Utp8p and Utp9p, must interact directly for the SSU processome to function properly...