| UTP4Gene Symbol: UTP4 Description: Utp4p Alias: Utp4p Species: Saccharomyces cerevisiae S288c Freed E, Baserga S. The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Nucleic Acids Res. 2010;38:4798-806 pubmed publisher ..Recently, a missense mutation in the C-terminus of an SSU processome protein, Utp4/Cirhin, was reported to cause North American Indian childhood cirrhosis (NAIC)... Gallagher J, Dunbar D, Granneman S, Mitchell B, Osheim Y, Beyer A, et al. RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev. 2004;18:2506-17 pubmed ..This association may thus represent an early step in the formation of the SSU processome. Our results indicate that rRNA transcription and pre-rRNA processing are coordinated via specific components of the SSU processome. .. Hoang T, Peng W, Vanrobays E, Krogan N, Hiley S, Beyer A, et al. Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol. 2005;25:5523-34 pubmed ..The identification of ABT1 in a large-scale analysis of the human nucleolar proteome indicates that its role may also be conserved in mammals. .. Dosil M. Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response. Mol Cell Biol. 2011;31:2422-38 pubmed publisher ..I propose that the functional duality of Rrp12 may couple the control of ribosome production to the regulation of other cellular processes during cell cycle progression. .. Leger Silvestre I, Milkereit P, Ferreira Cerca S, Saveanu C, Rousselle J, Choesmel V, et al. The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast. EMBO J. 2004;23:2336-47 pubmed ..We conclude that, during the final maturation steps in the nucleus, incorporation of the ribosomal protein Rps15p is specifically required to render the pre-40S particles competent for translocation to the cytoplasm. .. Pérez Fernández J, Roman A, De Las Rivas J, Bustelo X, Dosil M. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol. 2007;27:5414-29 pubmed ..Together, our data identify the mechanism of assembly of the 90S preribosome and offer novel information about its internal architecture. .. Segerstolpe A, Lundkvist P, Osheim Y, Beyer A, Wieslander L. Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes. Nucleic Acids Res. 2008;36:4364-80 pubmed publisher ..These results show that Mrd1p is required for establishing productive structures within the 90S preribosomal complex. .. Schilling V, Peifer C, Buchhaupt M, Lamberth S, Lioutikov A, Rietschel B, et al. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Yeast. 2012;29:167-83 pubmed publisher ..Our genetic and biochemical data suggest that Utp30 and Nep1 act together during pre-ribosomal complex formation and, along with Rps18, provide the surface for the Rps19 assembly to the 90S pre-ribosome. .. Frenk S, Oxley D, Houseley J. The nuclear exosome is active and important during budding yeast meiosis. PLoS ONE. 2014;9:e107648 pubmed publisher ..Together, our results show that the nuclear exosome remains active in meiosis and has an important role in facilitating meiotic recombination. ..
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