Gene Symbol: UPS2
Description: Ups2p
Alias: AIM30, GEP1, MSF1, MSF1', Ups2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Tamura Y, Onguka O, Hobbs A, Jensen R, Iijima M, Claypool S, et al. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem. 2012;287:15205-18 pubmed publisher
    ..Here, we investigated the role of the conserved intermembrane space proteins, Ups1p and Ups2p, and an inner membrane protein, Mdm31p, in phospholipid metabolism...
  2. Aaltonen M, Friedman J, Osman C, Salin B, di Rago J, Nunnari J, et al. MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J Cell Biol. 2016;213:525-34 pubmed publisher
    ..First, Ups2-Mdm35 complexes (SLMO2-TRIAP1 in humans) serve as phosphatidylserine (PS)-specific lipid transfer proteins in the ..
  3. Miyata N, Goda N, Matsuo K, Hoketsu T, Kuge O. Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae. Sci Rep. 2017;7:16447 pubmed publisher
    ..However, the CL accumulation in ups1? cells is enhanced by the depletion of Ups2, which forms a protein complex with Mdm35 and mediates phosphatidylserine (PS) transfer from the MOM to the MIM for ..
  4. Tamura Y, Endo T, Iijima M, Sesaki H. Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J Cell Biol. 2009;185:1029-45 pubmed publisher
    ..In this study, we report that two homologous intermembrane space proteins, Ups1p and Ups2p, control cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in an opposing ..
  5. Tamura Y, Iijima M, Sesaki H. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. EMBO J. 2010;29:2875-87 pubmed publisher
    Ups1p, Ups2p, and Ups3p are three homologous proteins that control phospholipid metabolism in the mitochondrial intermembrane space (IMS)...
  6. Potting C, Wilmes C, Engmann T, Osman C, Langer T. Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. 2010;29:2888-98 pubmed publisher
    ..Ups1 and Ups2 (also termed Gep1) were shown to regulate the accumulation of cardiolipin (CL) and phosphatidylethanolamine (PE), ..
  7. Hall B, Owens K, Singh K. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. J Biol Chem. 2011;286:39141-52 pubmed publisher
    ..In this study, we identify a novel LEA-like domain in a yeast PRELID1 homolog, Ups2p, which contains sequence conservation with the LEA domain of human PRELID1...
  8. Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool S, et al. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J Biol Chem. 2012;287:43961-71 pubmed publisher
    ..Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to regulate PE metabolism by controlling the export of PE...
  9. Joshi A, Fei N, Greenberg M. Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels. FEMS Yeast Res. 2016;16: pubmed publisher
    ..The genetic interactions observed in this study identify novel physiological modifiers that are required for maintenance of CL levels and mitochondrial morphology. ..

More Information


  1. Miyata N, Watanabe Y, Tamura Y, Endo T, Kuge O. Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria. J Cell Biol. 2016;214:77-88 pubmed publisher
    ..Here, we provide evidence that Ups2-Mdm35, a protein complex localized at the mitochondrial intermembrane space, mediates PS transport for PE synthesis ..