Gene Symbol: UGO1
Species: Saccharomyces cerevisiae S288c
Belenkiy R, Haefele A, Eisen M, Wohlrab H. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with . Biochim Biophys Acta. 2000;1467:207-18 pubmed
..Interestingly, yeast two-hybrid screens, that will also be useful in identifying the function of MTPs, indicate that MIR1, AAC3, YOR100C, and YPR011C do interact with non-MTPs. ..
Wong E, Wagner J, Scott S, Okreglak V, Holewinske T, Cassidy Stone A, et al
. The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J Cell Biol. 2003;160:303-11 pubmed
..Mitochondrial fusion requires two integral outer membrane components, Fzo1p and Ugo1p. Interestingly, mutations in a second mitochondrial-associated dynamin-related GTPase, Mgm1p, produce similar ..
Sesaki H, Southard S, Yaffe M, Jensen R. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell. 2003;14:2342-56 pubmed
In Saccharomyces cerevisiae, mitochondrial fusion requires at least two outer membrane proteins, Fzo1p and Ugo1p. We provide direct evidence that the dynamin-related Mgm1 protein is also required for mitochondrial fusion...
Sesaki H, Jensen R. Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem. 2004;279:28298-303 pubmed
In yeast, mitochondrial fusion requires Ugo1p and two GTPases, Fzo1p and Mgm1p. Ugo1p is anchored in the mitochondrial outer membrane with its N terminus facing the cytosol and C terminus in the intermembrane space...
Hoppins S, Horner J, Song C, McCaffery J, Nunnari J. Mitochondrial outer and inner membrane fusion requires a modified carrier protein. J Cell Biol. 2009;184:569-81 pubmed publisher
..The third essential component is Ugo1, an outer membrane protein in the mitochondrial transport protein family...
Sesaki H, Jensen R. UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol. 2001;152:1123-34 pubmed
..We find that UGO1 encodes a 58-kD protein located in the mitochondrial outer membrane. Ugo1p appears to contain a single transmembrane segment, with its NH(2) terminus facing the cytosol and its COOH ..
Coonrod E, Karren M, Shaw J. Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic. 2007;8:500-11 pubmed
..b>Ugo1p contains two putative carrier domains (PCDs) found in mitochondrial carrier proteins (MCPs)...
Papic D, Krumpe K, Dukanovic J, Dimmer K, Rapaport D. Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol. 2011;194:397-405 pubmed publisher
..In this paper, we address this issue using yeast mitochondria and the multispan protein Ugo1. Using a specific insertion assay and analysis by native gel electrophoresis, we show that the import receptor ..
Kang C, Jiang Y. Genome-wide survey of non-essential genes required for slowed DNA synthesis-induced filamentous growth in yeast. Yeast. 2005;22:79-90 pubmed
..protein secretion, SEC66, RPL21A and RPL34B; (d) genes encoding factors for normal mitochondrial function, IML1 and UGO1. These results showed that pseudohyphal formation involves not the only previously known regulation of the actin ..