Gene Symbol: TOM71
Description: protein channel TOM71
Alias: TOM72, protein channel TOM71
Species: Saccharomyces cerevisiae S288c
Burri L, Vascotto K, Gentle I, Chan N, Beilharz T, Stapleton D, et al
. Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae. FEBS J. 2006;273:1507-15 pubmed
..The alpha-helical outer membrane proteins provide functions derived after the endosymbiotic event, and require the translocase in the outer mitochondrial membrane complex for insertion into the outer membrane. ..
Schlossmann J, Lill R, Neupert W, Court D. Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. J Biol Chem. 1996;271:17890-5 pubmed
The protein Tom71 is encoded by the open reading frame YHR117w (yeast chromosome VIII) and shares 53% amino acid sequence identity with Tom70, a protein import receptor of the mitochondrial outer membrane...
Chan N, Likic V, Waller R, Mulhern T, Lithgow T. The C-terminal TPR domain of Tom70 defines a family of mitochondrial protein import receptors found only in animals and fungi. J Mol Biol. 2006;358:1010-22 pubmed
..Proteins that function equivalently to Tom70 may have arisen independently in plants and protists. ..
Kondo Okamoto N, Shaw J, Okamoto K. Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO Rep. 2008;9:63-9 pubmed
..general preprotein import receptor Tom70 (a component of translocase of the outer membrane) and its paralogue Tom71-are required for Mfb1 mitochondrial localization...
Li J, Qian X, Hu J, Sha B. Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading. J Biol Chem. 2009;284:23852-9 pubmed publisher
..Tom70/Tom71 is a major surface receptor of the translocase of the outer membrane complex for mitochondrial preproteins...
Papic D, Elbaz Alon Y, Koerdt S, Leopold K, Worm D, Jung M, et al
. The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein. Mol Cell Biol. 2013;33:4083-94 pubmed publisher
..We further observed lower steady-state levels of Mim1 in mitochondria from djp1? and tom70 tom71? cells and massive mislocalization of overexpressed GFP-Mim1 to the endoplasmic reticulum in the absence of Djp1...
Li J, Cui W, Sha B. The structural plasticity of Tom71 for mitochondrial precursor translocations. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:985-9 pubmed publisher
Mitochondrial precursors are transported through the translocase of the outer membrane (TOM) complex. Tom70/Tom71 is a major surface receptor of the TOM complex for mitochondrial precursors and facilitates Hsp70/Hsp90-escorted precursor ..