Gene Symbol: TOK1
Description: Tok1p
Alias: DUK1, YKC1, YPK1, Tok1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Proft M, Struhl K. MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell. 2004;118:351-61 pubmed
    ..which phosphorylates at least two proteins located at the plasma membrane, the Nha1 Na+/H+ antiporter and the Tok1 potassium channel...
  2. Hoeberichts F, Perez Valle J, Montesinos C, Mulet J, Planes M, Hueso G, et al. The role of K(+) and H(+) transport systems during glucose- and H(2)O(2)-induced cell death in Saccharomyces cerevisiae. Yeast. 2010;27:713-25 pubmed publisher
    ..A triple mutant ena1-4 tok1 nha1, devoid of K(+) efflux systems, is more tolerant to both glucose- and H(2)O(2)-induced cell death...
  3. Ketchum K, Joiner W, Sellers A, Kaczmarek L, Goldstein S. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature. 1995;376:690-5 pubmed
    ..Here we describe a novel K+ channel (TOK1) from Saccharomyces cerevisiae that contains two P domains within one continuous polypeptide...
  4. Johansson I, Blatt M. Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity. Biochem J. 2006;393:645-55 pubmed
    Gating of the outward-rectifying K+ channel TOK1 of Saccharomyces cerevisiae is controlled by membrane voltage and extracellular K+ concentration...
  5. Rios G, Ferrando A, Serrano R. Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae. Yeast. 1997;13:515-28 pubmed
    ..The effect of HAL1 on intracellular K+ was independent of the TRK1 and TOK1 genes, corresponding to a major K+ uptake system and to a K+ efflux system activated by depolarization, ..
  6. Zahradka J, Van Heusden G, Sychrova H. Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter. Biochim Biophys Acta. 2012;1820:849-58 pubmed publisher
    ..Our results showed for the first time that the yeast 14-3-3 proteins and an alkali-metal-cation efflux system interact and that this interaction enhances the cell survival upon salt stress. ..
  7. Fairman C, Zhou X, Kung C. Potassium uptake through the TOK1 K+ channel in the budding yeast. J Membr Biol. 1999;168:149-57 pubmed
    The current through TOK1 (YKC1), the outward-rectifying K+ channel in Saccharomyces cerevisiae, was amplified by expressing TOK1 from a plasmid driven by a strong constitutive promoter...
  8. Erez O, Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun. 2002;295:1142-9 pubmed LiCl and improved growth in low K(+) are partly dependent on the Nha1p and Kha1p antiporters and on the Tok1p channel...
  9. Roller A, Natura G, Bihler H, Slayman C, Bertl A. Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p. Pflugers Arch. 2008;456:883-96 pubmed publisher
    ..The resulting intrinsic asymmetry is exaggerated in fungal 2P channels, especially in Tok1p of Saccharomyces, by the N-terminal presence of four more transmembrane helices...

More Information


  1. Zahradka J, Sychrova H. Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions. FEMS Yeast Res. 2012;12:439-46 pubmed publisher
    ..efflux and uptake systems revealed that all three potassium-exporting systems the Nha1 antiporter, Ena ATPase and Tok1 channel contribute to potassium homeostasis and are active upon potassium limitation in wild-type cells...
  2. Roller A, Natura G, Bihler H, Slayman C, Eing C, Bertl A. In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance. Pflugers Arch. 2005;451:362-70 pubmed
    The yeast plasma-membrane potassium channel, Tok1p, is a voltage-dependent outward rectifier, the gating and steady-state conductance of which are conspicuously modulated by extracellular [K(+)] ([K(+)](o))...