Gene Symbol: TOF2
Species: Saccharomyces cerevisiae S288c
Johzuka K, Horiuchi T. The cis element and factors required for condensin recruitment to chromosomes. Mol Cell. 2009;34:26-35 pubmed publisher
..Instead, by genetic screening, we identified three genes, TOF2, CSM1, and LRS4, required both for condensin recruitment to the RFB site and for assuring the segregation of rDNA ..
Park H, Sternglanz R. Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast. 1999;15:35-41 pubmed
..Two new genes were found and named TOF1 and TOF2. The Tof1 protein has 1238 amino acids and no obvious homologues in databases...
Geil C, Schwab M, Seufert W. A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol. 2008;18:1001-5 pubmed publisher
..Cdc14 and Net1 are part of a larger nucleolar-protein network, which also contains the Net1-related protein Tof2. Tof2 contributes to the transcriptional silencing of rDNA regions, but the precise cellular and molecular ..
Zaman S, Choudhury M, Jiang J, Srivastava P, Mohanty B, Danielson C, et al
. Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. Mol Cell Biol. 2016;36:1451-63 pubmed publisher
..We show further that long-range Fob1-mediated Ter-Ter interactions in trans are downregulated by Sir2. These regulatory mechanisms control intrachromatid recombination and the replicative life span (RLS). ..
Villa F, Simon A, Ortiz Bazan M, Kilkenny M, Wirthensohn D, Wightman M, et al
. Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase. Mol Cell. 2016;63:385-96 pubmed publisher
..Mutations in the CIP-box motifs of the Dna2 nuclease or the rDNA-associated protein Tof2 do not perturb DNA synthesis genome-wide, but instead lead to a dramatic shortening of chromosome 12 that contains ..
Wysocka M, Rytka J, Kurlandzka A. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Exp Cell Res. 2004;294:592-602 pubmed
..We propose that, besides its other functions, Csm1p may be involved in premeiotic DNA replication. ..
Mekhail K, Seebacher J, Gygi S, Moazed D. Role for perinuclear chromosome tethering in maintenance of genome stability. Nature. 2008;456:667-70 pubmed publisher
..Our results therefore reveal an ancient mechanism in which interactions between INM proteins and chromosomal proteins ensure genome stability. ..
Corbett K, Yip C, Ee L, Walz T, Amon A, Harrison S. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010;142:556-67 pubmed publisher
..the same Csm1 point-mutations affect rDNA silencing, probably by disrupting binding to the rDNA-associated protein Tof2. We propose that Csm1/Lrs4 functions as a molecular clamp, crosslinking kinetochore components to enforce sister ..