Genomes and Genes
Gene Symbol: TKL1
Description: transketolase TKL1
Species: Saccharomyces cerevisiae S288c
- The pentose phosphate pathway in the endoplasmic reticulumC Bublitz
Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver 80262
J Biol Chem 263:12849-53. 1988..The activity of the microsomal pentose phosphate pathway is estimated to be about 1.5% that of the cytoplasmic pathway...
- Halogenated pyruvate derivatives as substrates of transketolase from Saccharomyces cerevisiaeO A Esakova
Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
Biochemistry (Mosc) 74:1234-8. 2009..The fundamental possibility was demonstrated of using halogenated pyruvate derivatives as donors of the halogen-hydroxyethyl group in organic synthesis of halogenated carbohydrates involving transketolase...
- Cooperative binding of substrates to transketolase from Saccharomyces cerevisiaeI A Sevostyanova
Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia
Biochemistry (Mosc) 74:789-92. 2009..In the presence of Mg2+, nonequivalence of the active sites is not observed...
- Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiaeShi Xiong Tan
Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Mol Biol Cell 20:1493-508. 2009..superoxide dismutase (SOD) function (SOD1, CCS1) or affected in NADPH generation via the pentose phosphate pathway (TKL1, RPE1)...
- Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectorsCarole D Carter
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Building 8, Room 5101, 8901 Wisconsin Ave, Bethesda, MD 20889 5105, USA
Mol Cell Biol 25:10273-85. 2005..The HU sensitivity of sod1Delta and lys7Delta strains is suppressed by overexpression of TKL1, a transketolase that generates NADPH, which balances redox in the cell and is required for ribonucleotide ..
- Binding of the coenzyme and formation of the transketolase active centerG A Kochetov
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
IUBMB Life 57:491-7. 2005....
- Donor substrate regulation of transketolaseOlga A Esakova
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
Eur J Biochem 271:4189-94. 2004..The enhancement of thiamin diphosphate's affinity to apotransketolase in the presence of donor substrate is probably one of the mechanisms underlying the substrate-affected transketolase regulation at low coenzyme concentrations...
- Kinetic study of the H103A mutant yeast transketolaseVitaliy A Selivanov
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119992 Moscow, GSP 2, Russia
FEBS Lett 567:270-4. 2004..Our results provide evidence for the intermediate-stabilizing function of His103...
- The yeast copper/zinc superoxide dismutase and the pentose phosphate pathway play overlapping roles in oxidative stress protectionK H Slekar
Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
J Biol Chem 271:28831-6. 1996..Here we report that these two sod1Delta phenotypes were specifically suppressed by elevated expression of the TKL1 gene, encoding transketolase of the pentose phosphate pathway...
- Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolaseM Walfridsson
Department of Applied Microbiology, Lund University, Sweden
Appl Environ Microbiol 61:4184-90. 1995..cerevisiae lacks. In order to increase the flux through the pentose phosphate pathway, the S. cerevisiae TKL1 and TAL1 genes encoding transketolase and transaldolase were overexpressed. A XYL1- and XYL2-containing S...
- Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenaseI Schaaff-Gerstenschlager
Institut fur Mikrobiologie, TH Darmstadt, Germany
Curr Genet 24:373-6. 1993Deletion mutants for the yeast transketolase gene TKL1 were constructed by gene replacement. Transketolase activity was below the level of detection in mutant crude extracts...
- Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acidsM Sundstrom
Department Molecular Biology, Swedish University of Agricultural Science, Uppsala Biomedical Center
J Biol Chem 268:24346-52. 1993A gene encoding transketolase, TKL1, was cloned from the budding yeast Saccharomyces cerevisiae using oligonucleotide primers derived from protein sequence data...
- TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the geneI Schaaff-Gerstenschlager
Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
Eur J Biochem 217:487-92. 1993..Yeast mutants with a deletion of the transketolase gene, TKL1, can grow without aromatic amino acid supplement indicating an additional source of erythrose 4-phosphate in the ..
- Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometryHamid Mirzaei
Institute for Systems Biology, Seattle, WA 98103, USA
Mol Biosyst 6:2004-14. 2010..cerevisiae. We then applied the method to detect toxin induced changes in the poly-ubiquitination profile in complex and enriched protein samples...