TKL1

Summary

Gene Symbol: TKL1
Description: transketolase TKL1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. doi Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae
    Akinori Matsushika
    Biomass Technology Research Center BTRC, National Institute of Advanced Industrial Science and Technology AIST, 3 11 32 Kagamiyama, Higashi Hiroshima, Hiroshima 739 0046, Japan
    Enzyme Microb Technol 51:16-25. 2012
  2. pmc Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry
    Hamid Mirzaei
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Biosyst 6:2004-14. 2010
  3. ncbi Halogenated pyruvate derivatives as substrates of transketolase from Saccharomyces cerevisiae
    O A Esakova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 74:1234-8. 2009
  4. ncbi Cooperative binding of substrates to transketolase from Saccharomyces cerevisiae
    I A Sevostyanova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia
    Biochemistry (Mosc) 74:789-92. 2009
  5. pmc Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae
    Shi Xiong Tan
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Mol Biol Cell 20:1493-508. 2009
  6. pmc Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors
    Carole D Carter
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Building 8, Room 5101, 8901 Wisconsin Ave, Bethesda, MD 20889 5105, USA
    Mol Cell Biol 25:10273-85. 2005
  7. ncbi Binding of the coenzyme and formation of the transketolase active center
    G A Kochetov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    IUBMB Life 57:491-7. 2005
  8. ncbi Donor substrate regulation of transketolase
    Olga A Esakova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Eur J Biochem 271:4189-94. 2004
  9. ncbi Kinetic study of the H103A mutant yeast transketolase
    Vitaliy A Selivanov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119992 Moscow, GSP 2, Russia
    FEBS Lett 567:270-4. 2004
  10. ncbi The yeast copper/zinc superoxide dismutase and the pentose phosphate pathway play overlapping roles in oxidative stress protection
    K H Slekar
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 271:28831-6. 1996

Scientific Experts

  • Akinori Matsushika
  • G A Kochetov
  • Hamid Mirzaei
  • Shi Xiong Tan
  • I A Sevostyanova
  • O A Esakova
  • Carole D Carter
  • Vitaliy A Selivanov
  • Olga A Esakova
  • Ludmilla E Meshalkina
  • Barbara Grimes
  • Alan Aderem
  • Richard S Rogers
  • Jimmy Eng
  • Ruedi Aebersold
  • Ian W Dawes
  • Yuen T Lam
  • V A Yurshev
  • V A Selivanov
  • S V Zabrodskaya
  • Mariati Teo
  • Gabriel G Perrone
  • L E Meshalkina
  • O N Solovjeva
  • R Golbik
  • Munira A Basrai
  • Wei Chun Au
  • Christopher M Babic
  • Lauren E Kitchen
  • Gerhard Hübner
  • Natalia V Kochevova
  • Marina V Kovina
  • Ralph Golbik
  • I Schaaff-Gerstenschlager
  • K H Slekar
  • M Walfridsson
  • D J Kosman
  • V C Culotta
  • M Sundstrom
  • F K Zimmermann
  • B Hahn-Hägerdal
  • M Penttila
  • S Keranen
  • J Hallborn
  • Y Lindqvist
  • U Hellman
  • H Feldmann
  • G Mannhaupt
  • G Schneider
  • H Ronne
  • I Vetter
  • C Bublitz
  • S Steavenson

Detail Information

Publications15

  1. doi Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae
    Akinori Matsushika
    Biomass Technology Research Center BTRC, National Institute of Advanced Industrial Science and Technology AIST, 3 11 32 Kagamiyama, Higashi Hiroshima, Hiroshima 739 0046, Japan
    Enzyme Microb Technol 51:16-25. 2012
    ..Overexpression of TAL1 and TKL1, the major transaldolase and transketolase genes, increases the flux from the pentose phosphate pathway into the ..
  2. pmc Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry
    Hamid Mirzaei
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Biosyst 6:2004-14. 2010
    ..cerevisiae. We then applied the method to detect toxin induced changes in the poly-ubiquitination profile in complex and enriched protein samples...
  3. ncbi Halogenated pyruvate derivatives as substrates of transketolase from Saccharomyces cerevisiae
    O A Esakova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 74:1234-8. 2009
    ..The fundamental possibility was demonstrated of using halogenated pyruvate derivatives as donors of the halogen-hydroxyethyl group in organic synthesis of halogenated carbohydrates involving transketolase...
  4. ncbi Cooperative binding of substrates to transketolase from Saccharomyces cerevisiae
    I A Sevostyanova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia
    Biochemistry (Mosc) 74:789-92. 2009
    ..In the presence of Mg2+, nonequivalence of the active sites is not observed...
  5. pmc Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae
    Shi Xiong Tan
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Mol Biol Cell 20:1493-508. 2009
    ..superoxide dismutase (SOD) function (SOD1, CCS1) or affected in NADPH generation via the pentose phosphate pathway (TKL1, RPE1)...
  6. pmc Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors
    Carole D Carter
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Building 8, Room 5101, 8901 Wisconsin Ave, Bethesda, MD 20889 5105, USA
    Mol Cell Biol 25:10273-85. 2005
    ..The HU sensitivity of sod1Delta and lys7Delta strains is suppressed by overexpression of TKL1, a transketolase that generates NADPH, which balances redox in the cell and is required for ribonucleotide ..
  7. ncbi Binding of the coenzyme and formation of the transketolase active center
    G A Kochetov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    IUBMB Life 57:491-7. 2005
    ....
  8. ncbi Donor substrate regulation of transketolase
    Olga A Esakova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Eur J Biochem 271:4189-94. 2004
    ..The enhancement of thiamin diphosphate's affinity to apotransketolase in the presence of donor substrate is probably one of the mechanisms underlying the substrate-affected transketolase regulation at low coenzyme concentrations...
  9. ncbi Kinetic study of the H103A mutant yeast transketolase
    Vitaliy A Selivanov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119992 Moscow, GSP 2, Russia
    FEBS Lett 567:270-4. 2004
    ..Our results provide evidence for the intermediate-stabilizing function of His103...
  10. ncbi The yeast copper/zinc superoxide dismutase and the pentose phosphate pathway play overlapping roles in oxidative stress protection
    K H Slekar
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 271:28831-6. 1996
    ..Here we report that these two sod1Delta phenotypes were specifically suppressed by elevated expression of the TKL1 gene, encoding transketolase of the pentose phosphate pathway...
  11. pmc Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase
    M Walfridsson
    Department of Applied Microbiology, Lund University, Sweden
    Appl Environ Microbiol 61:4184-90. 1995
    ..cerevisiae lacks. In order to increase the flux through the pentose phosphate pathway, the S. cerevisiae TKL1 and TAL1 genes encoding transketolase and transaldolase were overexpressed. A XYL1- and XYL2-containing S...
  12. ncbi Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase
    I Schaaff-Gerstenschlager
    Institut fur Mikrobiologie, TH Darmstadt, Germany
    Curr Genet 24:373-6. 1993
    Deletion mutants for the yeast transketolase gene TKL1 were constructed by gene replacement. Transketolase activity was below the level of detection in mutant crude extracts...
  13. ncbi Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids
    M Sundstrom
    Department Molecular Biology, Swedish University of Agricultural Science, Uppsala Biomedical Center
    J Biol Chem 268:24346-52. 1993
    A gene encoding transketolase, TKL1, was cloned from the budding yeast Saccharomyces cerevisiae using oligonucleotide primers derived from protein sequence data...
  14. ncbi TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene
    I Schaaff-Gerstenschlager
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 217:487-92. 1993
    ..Yeast mutants with a deletion of the transketolase gene, TKL1, can grow without aromatic amino acid supplement indicating an additional source of erythrose 4-phosphate in the ..
  15. ncbi The pentose phosphate pathway in the endoplasmic reticulum
    C Bublitz
    Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver 80262
    J Biol Chem 263:12849-53. 1988
    ..The activity of the microsomal pentose phosphate pathway is estimated to be about 1.5% that of the cytoplasmic pathway...