Gene Symbol: TIP41
Description: Tip41p
Alias: Tip41p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Jacinto E, Guo B, Arndt K, Schmelzle T, Hall M. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell. 2001;8:1017-26 pubmed
    ..Here, we describe TIP41, a conserved TAP42-interacting protein involved in the regulation of SIT4...
  2. González A, Ruiz A, Casamayor A, Arino J. Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1. Mol Cell Biol. 2009;29:2876-88 pubmed publisher
    ..Epitasis analysis indicates that the mutation of SIT4 or TIP41, encoding a Tap42-interacting protein, abolishes the sensitivity of the ptc1 strain to rapamycin and caffeine...
  3. Santhanam A, Hartley A, Düvel K, Broach J, Garrett S. PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryot Cell. 2004;3:1261-71 pubmed
    ..Effects of Tap42p inactivation and rapamycin addition could be suppressed by deletion of TIP41, which encodes a Tap42p-interacting protein...
  4. Dunn C, Jensen R. Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA. Genetics. 2003;165:35-45 pubmed
    ..Our results suggest that increased amounts of Cct6p, Ssb1p, Icy1p, Tip41p, and Pbp1p help overcome the problems resulting from a defect in protein import.
  5. Kuepfer L, Peter M, Sauer U, Stelling J. Ensemble modeling for analysis of cell signaling dynamics. Nat Biotechnol. 2007;25:1001-6 pubmed
    ..PP2As), our integrated computational and experimental analysis proposes a specificity factor, based on Tap42p-Tip41p, for PP2As as the key signaling mechanism that is quantitatively consistent with all available experimental data...
  6. Bruckner S, Kern S, Birke R, Saugar I, Ulrich H, Mösch H. The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics. 2011;189:479-94 pubmed publisher
    ..is under control of the nutrient-sensitive target of rapamycin complex 1 (TORC1) signaling pathway via the Tip41-Tap42-Sit4 branch...
  7. Oler A, Cairns B. PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. EMBO J. 2012;31:1440-52 pubmed publisher
    ..main Maf1 phosphatase, and define the involved catalytic (Pph3), scaffold (Psy2) and regulatory subunits (Rrd1, Tip41), as well as uninvolved subunits (Psy4, Rrd2)...
  8. González A, Casado C, Arino J, Casamayor A. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae. PLoS ONE. 2013;8:e64470 pubmed publisher
    ..These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters. ..
  9. Araki T, Uesono Y, Oguchi T, Toh e A. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Genes Genet Syst. 2005;80:325-43 pubmed
    ..Consistent with the broad cellular functions exerted by the TOR pathway, we found that Las24p was associated with membranes and was localized at vacuoles, the plasma membrane and small vesicles. ..

More Information


  1. Yorimitsu T, He C, Wang K, Klionsky D. Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy. 2009;5:616-24 pubmed
    ..Absence of the Tap42-interacting protein Tip41 abolished autophagy induction in the tap42 mutants, whereas overexpression of Tip41 activated autophagy...
  2. Stirling P, Bloom M, Solanki Patil T, Smith S, Sipahimalani P, Li Z, et al. The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet. 2011;7:e1002057 pubmed publisher
    ..Overall, the CIN gene spectrum reveals new chromosome biology and will help us to understand CIN phenotypes in human disease...
  3. Scheidt V, Jüdes A, Bär C, Klassen R, Schaffrath R. Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling. Microb Cell. 2014;1:416-424 pubmed publisher
    ..this involves inappropriate TOR signaling, we examined interaction between mutations in TOR pathway genes (tip41?, sap190?, ppm1?, rrd1?) and U34 modification defects (elp3?, kti12?, ..