Gene Symbol: TIM11
Description: F1F0 ATP synthase subunit e
Alias: ATP21, F1F0 ATP synthase subunit e
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Arnold I, Pfeiffer K, Neupert W, Stuart R, Schagger H. Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. EMBO J. 1998;17:7170-8 pubmed
    ..These dimer-specific subunits of the ATP synthase were identified as the recently described subunit e/Tim11 (Su e/Tim11), the putative subunit g homolog (Su g) and a new component termed subunit k (Su k)...
  2. Bornhovd C, Vogel F, Neupert W, Reichert A. Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes. J Biol Chem. 2006;281:13990-8 pubmed
    ..We propose a role for the supracomplexes of the F1F0-ATP synthase in organizing microdomains within the inner membrane, ensuring optimal bioenergetic competence of mitochondria. ..
  3. Fronzes R, Weimann T, Vaillier J, Velours J, Brèthes D. The peripheral stalk participates in the yeast ATP synthase dimerization independently of e and g subunits. Biochemistry. 2006;45:6715-23 pubmed
  4. Rabl R, Soubannier V, Scholz R, Vogel F, Mendl N, Vasiljev Neumeyer A, et al. Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol. 2009;185:1047-63 pubmed publisher
    ..We propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate CJs and cristae tips. ..
  5. Wagner K, Rehling P, Sanjuán Szklarz L, Taylor R, Pfanner N, van der Laan M. Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. J Mol Biol. 2009;392:855-61 pubmed publisher
    ..Two small proteins of the membrane-embedded F(o)-domain, subunit e (Su e; Atp21) and Su g (Atp20), were identified as dimer-specific subunits of yeast ATP synthase and shown to be required for ..
  6. Arnold I, Pfeiffer K, Neupert W, Stuart R, Schagger H. ATP synthase of yeast mitochondria. Isolation of subunit j and disruption of the ATP18 gene. J Biol Chem. 1999;274:36-40 pubmed
    ..In the absence of Su j, spontaneously arising rho- cells were observed that lacked also ubiquinol-cytochrome c reductase and cytochrome c oxidase activities. We conclude that Su j is a novel and essential subunit of yeast ATP synthase. ..
  7. Wagner K, Perschil I, Fichter C, van der Laan M. Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i. Mol Biol Cell. 2010;21:1494-504 pubmed publisher
    ..Several subunits were mapped to monomer-monomer-interfaces of yeast ATP synthase complexes, but only Su e (Atp21) and Su g (Atp20) have so far been identified as crucial for the formation of stable dimers...
  8. Itoh K, Tamura Y, Iijima M, Sesaki H. Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology. Mol Biol Cell. 2013;24:1842-51 pubmed publisher
    ..Our findings suggest an unexpected role of Fcj1-Mos1 and organelle division in maintaining the distribution and size of mtDNA nucleoids. ..
  9. Turakhiya U, von der Malsburg K, Gold V, Guiard B, Chacinska A, van der Laan M, et al. Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential. J Mol Biol. 2016;428:1041-1052 pubmed publisher
    ..Second, they directly demonstrate the role of the membrane potential in driving the electrophoretic transport of positively charged protein segments across the inner membrane. ..

More Information


  1. Brunner S, Everard Gigot V, Stuart R. Su e of the yeast F1Fo-ATP synthase forms homodimers. J Biol Chem. 2002;277:48484-9 pubmed
    ..Finally, we propose a model for the molecular basis of the homodimerization of the Su e proteins. ..
  2. Everard Gigot V, Dunn C, Dolan B, Brunner S, Jensen R, Stuart R. Functional analysis of subunit e of the F1Fo-ATP synthase of the yeast Saccharomyces cerevisiae: importance of the N-terminal membrane anchor region. Eukaryot Cell. 2005;4:346-55 pubmed
    ..Finally, we propose a model to explain how Su e supports the assembly of the ATP synthase dimers-oligomers in the mitochondrial membrane. ..
  3. Saddar S, Stuart R. The yeast F(1)F(0)-ATP synthase: analysis of the molecular organization of subunit g and the importance of a conserved GXXXG motif. J Biol Chem. 2005;280:24435-42 pubmed
    ..We suggest that the GXXXG motif may not be the sole basis for a Su g-Su e interaction, and possibly these dimerization motifs may enable both Su g and Su e to interact with another mitochondrial protein. ..
  4. Förster K, Turina P, Drepper F, Haehnel W, Fischer S, Graber P, et al. Proton transport coupled ATP synthesis by the purified yeast H+ -ATP synthase in proteoliposomes. Biochim Biophys Acta. 2010;1797:1828-37 pubmed publisher
    ..The dependence of the turnover on the phosphate concentration and the dependence of K(M) on pH(out) indicated that the substrate for ATP synthesis is the monoanionic phosphate species H?PO??. ..
  5. Harner M, Unger A, Geerts W, Mari M, Izawa T, Stenger M, et al. An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation. elife. 2016;5: pubmed publisher
    ..The proposed hypothesis is suggested to apply also to higher eukaryotes, since the key components are conserved in structure and function throughout evolution. ..
  6. Arnold I, Bauer M, Brunner M, Neupert W, Stuart R. Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett. 1997;411:195-200 pubmed
    ..Subunit e had been previously identified as Tim11 and was proposed to be involved in the process of sorting of proteins to the mitochondrial inner membrane.
  7. Giraud M, Paumard P, Soubannier V, Vaillier J, Arselin G, Salin B, et al. Is there a relationship between the supramolecular organization of the mitochondrial ATP synthase and the formation of cristae?. Biochim Biophys Acta. 2002;1555:174-80 pubmed
    ..We provide a model in which the mitochondrial ATP synthase is a key element in cristae morphogenesis. ..