THI72

Summary

Gene Symbol: THI72
Description: thiamine transporter
Alias: thiamine transporter
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Mojzita D, Hohmann S. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics. 2006;276:147-61 pubmed
    ..In conclusion, the THI regulon is the most interesting system to study principles of genes expression and metabolic coordination and deserves further attention. ..
  2. Vogl C, Klein C, Batke A, Schweingruber M, Stolz J. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. J Biol Chem. 2008;283:7379-89 pubmed publisher
    ..We have isolated the S. pombe thiamine transporter Thi9 by genetic complementation of mutants defective in thiamine biosynthesis and transport...
  3. Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W, et al. Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLoS Genet. 2012;8:e1003083 pubmed publisher
    ..In addition, CQ completely inhibited a human thiamine transporter (SLC19A3) expressed in yeast and significantly inhibited thiamine uptake in cultured human cell lines...
  4. Ceschin J, Saint Marc C, Laporte J, Labriet A, Philippe C, Moenner M, et al. Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-?-d-ribofuranoside (AICAr) transporters. J Biol Chem. 2014;289:16844-54 pubmed publisher
    ..Identification of the cognate genes allowed us to establish that thiamine transporters Thi7 and Thi72 can efficiently take up AICAr under conditions where they are overexpressed...
  5. Enjo F, Nosaka K, Ogata M, Iwashima A, Nishimura H. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. J Biol Chem. 1997;272:19165-70 pubmed
    ..Northern blot analysis demonstrated that THI10 gene expression is regulated at the mRNA level by intracellular thiamin pyrophosphate and that it requires a positive regulatory factor encoded by THI3 gene. ..

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